LongevityMap variant group
Entry Details
- Longevity Association
- Non-significant
- Population
- American of Japanese origin
- Study Design
- Nested-case control study of 5 candidate longevity genes in 8006 Japanese American men from the Honolulu Heart Program and 3741 men part of the Honolulu Asia Aging Study
- Conclusions
- Genetic variants in ADIPOQ, FOXO1A, SIRT1 and COQ7 were not associated with longevity
Variants (12)
- Gene summary:
- ADIPOQ (3)
- COQ7 (3)
- FOXO1 (3)
- SIRT1 (3)
ADIPOQ
Gene details
- HGNC symbol
- ADIPOQ
- Aliases
- ACDC; ADPN; APM1; APM-1; GBP28; ACRP30; ADIPQTL1
- Common name
- adiponectin, C1Q and collagen domain containing
- Description
- This gene is expressed in adipose tissue exclusively. It encodes a protein with similarity to collagens X and VIII and complement factor C1q. The encoded protein circulates in the plasma and is involved with metabolic and hormonal processes. Mutations in this gene are associated with adiponectin deficiency. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Apr 2010]
- Other longevity studies of this gene
- 8
- OMIM
- 605441
- Ensembl
- ENSG00000181092
- UniProt/Swiss-Prot
- A8K660_HUMAN
- Entrez Gene
- 9370
- UniGene
- 80485
- HapMap
- View on HapMap
Homologs in model organisms
COQ7
Gene details
- HGNC symbol
- COQ7
- Aliases
- CAT5; CLK1; CLK-1; COQ10D8
- Common name
- coenzyme Q7, hydroxylase
- Description
- The protein encoded by this gene is similar to a mitochondrial di-iron containing hydroxylase in Saccharomyces cerevisiae that is involved with ubiquinone biosynthesis. Mutations in the yeast gene lead to slower development and longer life span. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2010]
- Other longevity studies of this gene
- 2
- OMIM
- 601683
- Ensembl
- ENSG00000167186
- UniProt/Swiss-Prot
- COQ7_HUMAN
- Entrez Gene
- 10229
- UniGene
- 157113
- HapMap
- View on HapMap
Homologs in model organisms
- Caenorhabditis elegans
- clk-1
- Danio rerio
- zgc:158731
- Drosophila melanogaster
- COQ7
- Mus musculus
- Coq7
- Rattus norvegicus
- Coq7
- Saccharomyces cerevisiae
- CAT5
- Schizosaccharomyces pombe
- coq7
In other databases
FOXO1
Gene details
- HGNC symbol
- FOXO1
- Aliases
- FKH1; FKHR; FOXO1A
- Common name
- forkhead box O1
- Description
- This gene belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. The specific function of this gene has not yet been determined; however, it may play a role in myogenic growth and differentiation. Translocation of this gene with PAX3 has been associated with alveolar rhabdomyosarcoma. [provided by RefSeq, Jul 2008]
- Other longevity studies of this gene
- 30
- OMIM
- 136533
- Ensembl
- ENSG00000150907
- UniProt/Swiss-Prot
- FOXO1_HUMAN
- Entrez Gene
- 2308
- UniGene
- 370666
- HapMap
- View on HapMap
Homologs in model organisms
In other databases
SIRT1
Gene details
- HGNC symbol
- SIRT1
- Aliases
- SIR2; SIR2L1; SIR2alpha
- Common name
- sirtuin 1
- Description
- This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2008]
- Other longevity studies of this gene
- 33
- OMIM
- 604479
- Ensembl
- ENSG00000096717
- UniProt/Swiss-Prot
- A0A024QZQ1_HUMAN
- Entrez Gene
- 23411
- UniGene
- 369779
- HapMap
- View on HapMap
Homologs in model organisms
- Caenorhabditis elegans
- sir-2.1
- Danio rerio
- sirt1
- Drosophila melanogaster
- Sir2
- Mus musculus
- Sirt1
- Rattus norvegicus
- Sirt1