LongevityMap variant group
Entry Details
- Longevity Association
- Significant
- Population
- Ashkenazi Jewish
- Study Design
- 205 centenarians (141 females, median age = 97 years and 64 males, median age = 97 years), their offspring (n = 145 total, 80 females, median age = 69 years and 65 males median age = 68 years), and 288 controls (167 females, median age = 74 years and 121 males, median age = 75 years) were examined for the association between genotype and longevity
- Conclusions
- A U-shape pattern of MTP CC genotype frequency with aging was observed. The CC was a buffered-deleterious genotype in the case group. In the control group without longevity genes, CC genotype included poorer survivorship.
Variants (4)
- Gene summary:
- ADIPOQ (1)
- APOC3 (1)
- CETP (1)
- MTTP (1)
ADIPOQ
Gene details
- HGNC symbol
- ADIPOQ
- Aliases
- ACDC; ADPN; APM1; APM-1; GBP28; ACRP30; ADIPQTL1
- Common name
- adiponectin, C1Q and collagen domain containing
- Description
- This gene is expressed in adipose tissue exclusively. It encodes a protein with similarity to collagens X and VIII and complement factor C1q. The encoded protein circulates in the plasma and is involved with metabolic and hormonal processes. Mutations in this gene are associated with adiponectin deficiency. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Apr 2010]
- Other longevity studies of this gene
- 8
- OMIM
- 605441
- Ensembl
- ENSG00000181092
- UniProt/Swiss-Prot
- A8K660_HUMAN
- Entrez Gene
- 9370
- UniGene
- 80485
- HapMap
- View on HapMap
Homologs in model organisms
APOC3
Gene details
- HGNC symbol
- APOC3
- Aliases
- HALP2; APOCIII
- Common name
- apolipoprotein C3
- Description
- Apolipoprotein C-III is a very low density lipoprotein (VLDL) protein. APOC3 inhibits lipoprotein lipase and hepatic lipase; it is thought to delay catabolism of triglyceride-rich particles. The APOA1, APOC3 and APOA4 genes are closely linked in both rat and human genomes. The A-I and A-IV genes are transcribed from the same strand, while the A-1 and C-III genes are convergently transcribed. An increase in apoC-III levels induces the development of hypertriglyceridemia. [provided by RefSeq, Jul 2008]
- Other longevity studies of this gene
- 7
- OMIM
- 107720
- Ensembl
- ENSG00000110245
- UniProt/Swiss-Prot
- A3KPE2_HUMAN
- Entrez Gene
- 345
- UniGene
- 73849
- HapMap
- View on HapMap
Homologs in model organisms
In other databases
- GenAge human genes
- This gene is present as APOC3
CETP
Gene details
- HGNC symbol
- CETP
- Aliases
- BPIFF; HDLCQ10
- Common name
- cholesteryl ester transfer protein
- Description
- The protein encoded by this gene is found in plasma, where it is involved in the transfer of cholesteryl ester from high density lipoprotein (HDL) to other lipoproteins. Defects in this gene are a cause of hyperalphalipoproteinemia 1 (HALP1). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2013]
- Other longevity studies of this gene
- 17
- OMIM
- 118470
- Ensembl
- ENSG00000087237
- UniProt/Swiss-Prot
- A0A0S2Z3F6_HUMAN
- Entrez Gene
- 1071
- UniGene
- 89538
- HapMap
- View on HapMap
Homologs in model organisms
- Danio rerio
- cetp
In other databases
- GenAge human genes
- This gene is present as CETP
MTTP
Gene details
- HGNC symbol
- MTTP
- Aliases
- ABL; MTP
- Common name
- microsomal triglyceride transfer protein
- Description
- MTP encodes the large subunit of the heterodimeric microsomal triglyceride transfer protein. Protein disulfide isomerase (PDI) completes the heterodimeric microsomal triglyceride transfer protein, which has been shown to play a central role in lipoprotein assembly. Mutations in MTP can cause abetalipoproteinemia. [provided by RefSeq, Jul 2008]
- Other longevity studies of this gene
- 20
- OMIM
- 157147
- Ensembl
- ENSG00000138823
- UniProt/Swiss-Prot
- B7Z7X3_HUMAN
- Entrez Gene
- 4547
- UniGene
- 195799
- HapMap
- View on HapMap