GenAge entry for ATF2 (Homo sapiens)

Gene name (HAGRID: 193)

HGNC symbol
ATF2 
Aliases
TREB7; CRE-BP1; HB16; CREB2 
Common name
activating transcription factor 2 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on evidence showing that the gene product to be a target of genes previously linked to ageing
Description

ATF2 is an important transcription factor involved in a variety of functions that may also be involved in oxidative stress response [135] and cellular growth arrest and senescence [137]. It has not been directly related to human ageing.

Cytogenetic information

Cytogenetic band
2q32
Location
175,072,250 bp to 175,168,206 bp
Orientation
Minus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0000122; negative regulation of transcription from RNA polymerase II promoter
GO:0003151; outflow tract morphogenesis
GO:0006355; regulation of transcription, DNA-templated
GO:0006357; regulation of transcription from RNA polymerase II promoter
GO:0006366; transcription from RNA polymerase II promoter
GO:0006970; response to osmotic stress
GO:0006974; cellular response to DNA damage stimulus
GO:0009414; response to water deprivation
GO:0016573; histone acetylation
GO:0031573; intra-S DNA damage checkpoint
GO:0032915; positive regulation of transforming growth factor beta2 production
GO:0043525; positive regulation of neuron apoptotic process
GO:0045444; fat cell differentiation
GO:0045944; positive regulation of transcription from RNA polymerase II promoter
GO:0050680; negative regulation of epithelial cell proliferation
GO:0051090; regulation of sequence-specific DNA binding transcription factor activity
GO:0051091; positive regulation of sequence-specific DNA binding transcription factor activity
GO:0060612; adipose tissue development
GO:0097186; amelogenesis
GO:1902110; positive regulation of mitochondrial membrane permeability involved in apoptotic process
Cellular component: GO:0005634; nucleus
GO:0005654; nucleoplasm
GO:0005737; cytoplasm
GO:0005741; mitochondrial outer membrane
GO:0035861; site of double-strand break
Function: GO:0000977; RNA polymerase II regulatory region sequence-specific DNA binding
GO:0000980; RNA polymerase II distal enhancer sequence-specific DNA binding
GO:0001076; transcription factor activity, RNA polymerase II transcription factor binding
GO:0001077; transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0001102; RNA polymerase II activating transcription factor binding
GO:0001158; enhancer sequence-specific DNA binding
GO:0001228; transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
GO:0003682; chromatin binding
GO:0003700; transcription factor activity, sequence-specific DNA binding
GO:0003705; transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
GO:0003713; transcription coactivator activity
GO:0004402; histone acetyltransferase activity
GO:0005515; protein binding
GO:0008140; cAMP response element binding protein binding
GO:0019901; protein kinase binding
GO:0035497; cAMP response element binding
GO:0046872; metal ion binding
GO:0046982; protein heterodimerization activity
Hide GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
ATM, PTPN1, NBN, FOS, CREBBP, HSP90AA1, UBE2I, CEBPA, CEBPB, EP300, PML, EEF2, PCNA, RB1, APP, ATP5O, GSTP1, HSPD1, MAPK8, MAPK14, JUN, MAPK9, MAPK3, CREB1, ATF2, DDIT3, SUMO1, H2AFX, CTNNB1, MLH1
STRING interaction network
Protein-Protein network diagram for ATF2

Retrieve sequences for ATF2

ORF
ORF
CDS
CDS

Homologs in model organisms

Danio rerio
atf2
Mus musculus
Atf2
Rattus norvegicus
Atf2

Selected references

External links

EPD
ORF Accession
NM_001880
CDS Accession
NP_001871
OMIM
123811
HPRD
00443
Ensembl
ATF2
UniProt/Swiss-Prot
ATF2_HUMAN
GeneCards
ATF2
Entrez Gene
1386
UniGene
705370
GenAtlas
ATF2
Internet
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