Cell Senescence Entries for PTGS2

Cell Types
Foreskin fibroblast
Cell Lines
NHDF
Cancer Cell?
No
Method
Overexpression
Type of senescence
Replicative, Stress-induced
Senescence Effect
Induces
Primary Reference
Cormenier et al. (2018) The ATF6α arm of the Unfolded Protein Response mediates replicative senescence in human fibroblasts through a COX2/prostaglandin E2 intracrine pathway. Mech Ageing Dev 170(2)82-91 (PubMed)

PTGS2 Gene Information

HGNC symbol
PTGS2 
Aliases
COX2 
Common name
prostaglandin-endoperoxide synthase 2 
Entrez Id
5743
Description
Prostaglandin-endoperoxide synthase (PTGS), also known as cyclooxygenase, is the key enzyme in prostaglandin biosynthesis, and acts both as a dioxygenase and as a peroxidase. There are two isozymes of PTGS: a constitutive PTGS1 and an inducible PTGS2, which differ in their regulation of expression and tissue distribution. This gene encodes the inducible isozyme. It is regulated by specific stimulatory events, suggesting that it is responsible for the prostanoid biosynthesis involved in inflammation and mitogenesis. [provided by RefSeq, Feb 2009].

PTGS2 Ontologies

Gene Ontology
Process: GO:6629; lipid metabolic process
GO:6631; fatty acid metabolic process
GO:6633; fatty acid biosynthetic process
GO:6954; inflammatory response
GO:8217; regulation of blood pressure
GO:1516; prostaglandin biosynthetic process
GO:6693; prostaglandin metabolic process
GO:98869; cellular oxidant detoxification
GO:6979; response to oxidative stress
GO:19371; cyclooxygenase pathway
GO:90050; positive regulation of cell migration involved in sprouting angiogenesis
And 66 more GO terms
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:16020; membrane
GO:43231; intracellular membrane-bounded organelle
GO:5783; endoplasmic reticulum
GO:5789; endoplasmic reticulum membrane
GO:5637; nuclear inner membrane
GO:5640; nuclear outer membrane
GO:43005; neuron projection
GO:5788; endoplasmic reticulum lumen
GO:5901; caveola
And 2 more GO terms
Function: GO:46872; metal ion binding
GO:16491; oxidoreductase activity
GO:51213; dioxygenase activity
GO:5515; protein binding
GO:20037; heme binding
GO:19899; enzyme binding
GO:4601; peroxidase activity
GO:4666; prostaglandin-endoperoxide synthase activity
GO:16702; oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
GO:42803; protein homodimerization activity
Show all GO terms

Homologs of PTGS2 in Model Organisms

Danio rerio
ptgs2b
Mus musculus
Ptgs2
Rattus norvegicus
Ptgs2

In other databases

GenAge human genes
  • This gene is present as PTGS2

External links

OMIM
600262
Ensembl
ENSG00000073756
Entrez Gene
5743
UniGene
196384
1000 Genomes
1000 Genomes
HPRD
GenAtlas
PTGS2
GeneCards
PTGS2