GenAge entry for PTGS2 (Homo sapiens)

Gene name (HAGRID: 198)

HGNC symbol: PTGS2
Aliases: COX2
Common name: prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)

Potential relevance to the human ageing process

Main reason for selection: Entry selected based on indirect or inconclusive evidence linking the gene product to ageing in humans or in one or more model systems
Description: PTGS2 may play a role in inflammation. PTGS2-null mice developed severe nephropathy [864] and female reproductive failures [1734]. Age-related changes in PTGS2 have been reported in various tissues in mice [863]. PTGS2 has not been directly related to human ageing.

Cytogenetic information

Cytogenetic band: 1q25.2-q25
Location: 186,671,812 bp to 186,680,427 bp
Orientation: Minus strand

Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology

Process:

GO:0001516; prostaglandin biosynthetic process
GO:0001525; angiogenesis
GO:0006693; prostaglandin metabolic process
GO:0006769; nicotinamide metabolic process
GO:0006928; movement of cell or subcellular component
GO:0006954; inflammatory response
GO:0006979; response to oxidative stress
GO:0007566; embryo implantation
GO:0007612; learning
GO:0007613; memory
GO:0008217; regulation of blood pressure

And 49 more GO terms

Cellular component:

GO:0005634; nucleus
GO:0005737; cytoplasm
GO:0005783; endoplasmic reticulum
GO:0005788; endoplasmic reticulum lumen
GO:0005789; endoplasmic reticulum membrane
GO:0005901; caveola
GO:0031090; organelle membrane
GO:0043005; neuron projection
GO:0043234; protein complex

Function:

GO:0004601; peroxidase activity
GO:0004666; prostaglandin-endoperoxide synthase activity
GO:0005515; protein binding
GO:0008289; lipid binding
GO:0019899; enzyme binding
GO:0020037; heme binding
GO:0042803; protein homodimerization activity
GO:0046872; metal ion binding
GO:0050473; arachidonate 15-lipoxygenase activity

Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge: TP53, VCP, EP300, APP, MAPK3, PTGS2, SUMO1, CTNNB1
STRING interaction network

Retrieve sequences for PTGS2

ORF: ORF
CDS: CDS

Homologs in model organisms

Danio rerio: ptgs2b
Mus musculus: Ptgs2
Rattus norvegicus: Ptgs2

In other databases

CellAge

This gene is present as PTGS2