Cell Senescence Entries for SIRT2

Cell Types
Foreskin fibroblast
Cell Lines
BJ
Cancer Cell?
No
Method
Knockdown
Type of senescence
Unclear
Senescence Effect
Inhibits
Primary Reference
Kilic Eren et al. (2016) Resveratrol Induced Premature Senescence Is Associated with DNA Damage Mediated SIRT1 and SIRT2 Down-Regulation. PLoS One 10(4)e0124837 (PubMed)

SIRT2 Gene Information

HGNC symbol
SIRT2 
Aliases
SIR2L 
Common name
sirtuin 2 
Entrez Id
22933
Description
This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Several transcript variants are resulted from alternative splicing of this gene. [provided by RefSeq, Jul 2010].

SIRT2 Ontologies

Gene Ontology
Process: GO:7049; cell cycle
GO:45892; negative regulation of transcription, DNA-templated
GO:51301; cell division
GO:30154; cell differentiation
GO:6476; protein deacetylation
GO:16575; histone deacetylation
GO:45944; positive regulation of transcription by RNA polymerase II
GO:6914; autophagy
GO:122; negative regulation of transcription by RNA polymerase II
GO:2376; immune system process
GO:45087; innate immune response
And 50 more GO terms
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:16020; membrane
GO:5730; nucleolus
GO:5829; cytosol
GO:5886; plasma membrane
GO:5814; centriole
GO:5856; cytoskeleton
GO:5694; chromosome
GO:42995; cell projection
GO:5874; microtubule
And 21 more GO terms
Function: GO:70403; NAD+ binding
GO:46872; metal ion binding
GO:16740; transferase activity
GO:8270; zinc ion binding
GO:34979; NAD-dependent protein deacetylase activity
GO:17136; NAD-dependent histone deacetylase activity
GO:51287; NAD binding
GO:5515; protein binding
GO:43130; ubiquitin binding
GO:4407; histone deacetylase activity
GO:42826; histone deacetylase binding
And 8 more GO terms
Show all GO terms

Homologs of SIRT2 in Model Organisms

Danio rerio
sirt2
Drosophila melanogaster
Sirt2
Mus musculus
Sirt2
Rattus norvegicus
Sirt2
Saccharomyces cerevisiae
HST2
Schizosaccharomyces pombe
hst2

In other databases

GenAge model organism genes
  • A homolog of this gene for Saccharomyces cerevisiae is present as HST2
  • A homolog of this gene for Drosophila melanogaster is present as Sirt2
GenDR gene manipulations
  • A homolog of this gene for Saccharomyces cerevisiae is present as HST2

External links

OMIM
604480
Ensembl
ENSG00000068903
Entrez Gene
22933
UniGene
466693
1000 Genomes
1000 Genomes
HPRD
GenAtlas
SIRT2
GeneCards
SIRT2