Cell Senescence Entries for BCL2

Cell Types
Lung fibroblast
Cell Lines
IMR-90
Cancer Cell?
No
Method
Overexpression
Type of senescence
Oncogene-induced
Senescence Effect
Induces
Primary Reference
Tombor et al. (2003) Bcl-2 promotes premature senescence induced by oncogenic Ras. Biochem Biophys Res Commun 303(3)800-7 (PubMed)

BCL2 Gene Information

HGNC symbol
BCL2 
Aliases
Bcl-2; PPP1R50 
Common name
BCL2 apoptosis regulator 
Entrez Id
596
Description
This gene encodes an integral outer mitochondrial membrane protein that blocks the apoptotic death of some cells such as lymphocytes. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016].

BCL2 Ontologies

Gene Ontology
Process: GO:43066; negative regulation of apoptotic process
GO:6915; apoptotic process
GO:42981; regulation of apoptotic process
GO:12501; programmed cell death
GO:6974; cellular response to DNA damage stimulus
GO:51607; defense response to virus
GO:43065; positive regulation of apoptotic process
GO:80135; regulation of cellular response to stress
GO:55085; transmembrane transport
GO:9410; response to xenobiotic stimulus
GO:8630; intrinsic apoptotic signaling pathway in response to DNA damage
GO:97192; extrinsic apoptotic signaling pathway in absence of ligand
GO:1836; release of cytochrome c from mitochondria
GO:51902; negative regulation of mitochondrial depolarization
GO:7565; female pregnancy
GO:50853; B cell receptor signaling pathway
GO:8284; positive regulation of cell population proliferation
GO:2001243; negative regulation of intrinsic apoptotic signaling pathway
GO:9314; response to radiation
GO:1902166; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:10507; negative regulation of autophagy
GO:6959; humoral immune response
GO:209; protein polyubiquitination
GO:8625; extrinsic apoptotic signaling pathway via death domain receptors
GO:22898; regulation of transmembrane transporter activity
GO:30890; positive regulation of B cell proliferation
GO:2000811; negative regulation of anoikis
GO:9636; response to toxic substance
GO:30307; positive regulation of cell growth
GO:34097; response to cytokine
GO:42100; B cell proliferation
GO:43524; negative regulation of neuron apoptotic process
GO:51924; regulation of calcium ion transport
GO:70059; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO:2001240; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
GO:10039; response to iron ion
GO:32469; endoplasmic reticulum calcium ion homeostasis
GO:32848; negative regulation of cellular pH reduction
GO:35094; response to nicotine
GO:46902; regulation of mitochondrial membrane permeability
GO:51402; neuron apoptotic process
GO:51881; regulation of mitochondrial membrane potential
GO:2001234; negative regulation of apoptotic signaling pathway
GO:902; cell morphogenesis
GO:1503; ossification
GO:1541; ovarian follicle development
GO:1656; metanephros development
GO:1657; ureteric bud development
GO:1658; branching involved in ureteric bud morphogenesis
GO:1662; behavioral fear response
GO:1776; leukocyte homeostasis
GO:1782; B cell homeostasis
GO:1822; kidney development
GO:1952; regulation of cell-matrix adhesion
GO:2260; lymphocyte homeostasis
GO:2320; lymphoid progenitor cell differentiation
GO:2326; B cell lineage commitment
GO:2360; T cell lineage commitment
GO:2520; immune system development
GO:2931; response to ischemia
GO:3014; renal system process
GO:6470; protein dephosphorylation
GO:6582; melanin metabolic process
GO:6808; regulation of nitrogen utilization
GO:6874; cellular calcium ion homeostasis
GO:6979; response to oxidative stress
GO:7015; actin filament organization
GO:7409; axonogenesis
GO:7569; cell aging
GO:8283; cell population proliferation
GO:8285; negative regulation of cell population proliferation
GO:8584; male gonad development
GO:8631; intrinsic apoptotic signaling pathway in response to oxidative stress
GO:8637; apoptotic mitochondrial changes
GO:9605; response to external stimulus
GO:9791; post-embryonic development
GO:9887; animal organ morphogenesis
GO:10224; response to UV-B
GO:10332; response to gamma radiation
GO:10468; regulation of gene expression
GO:10506; regulation of autophagy
GO:10523; negative regulation of calcium ion transport into cytosol
GO:10559; regulation of glycoprotein biosynthetic process
GO:14031; mesenchymal cell development
GO:14042; positive regulation of neuron maturation
GO:14911; positive regulation of smooth muscle cell migration
GO:18105; peptidyl-serine phosphorylation
GO:18107; peptidyl-threonine phosphorylation
GO:21747; cochlear nucleus development
GO:22612; gland morphogenesis
GO:30097; hemopoiesis
GO:30183; B cell differentiation
GO:30217; T cell differentiation
GO:30279; negative regulation of ossification
GO:30308; negative regulation of cell growth
GO:30318; melanocyte differentiation
GO:30336; negative regulation of cell migration
GO:31069; hair follicle morphogenesis
GO:31103; axon regeneration
GO:31647; regulation of protein stability
GO:32835; glomerulus development
GO:32880; regulation of protein localization
GO:33033; negative regulation of myeloid cell apoptotic process
GO:33077; T cell differentiation in thymus
GO:33138; positive regulation of peptidyl-serine phosphorylation
GO:33689; negative regulation of osteoblast proliferation
GO:35265; organ growth
GO:40008; regulation of growth
GO:40018; positive regulation of multicellular organism growth
GO:42149; cellular response to glucose starvation
GO:42542; response to hydrogen peroxide
GO:43029; T cell homeostasis
GO:43067; regulation of programmed cell death
GO:43085; positive regulation of catalytic activity
GO:43375; CD8-positive, alpha-beta T cell lineage commitment
GO:43473; pigmentation
GO:43583; ear development
GO:45069; regulation of viral genome replication
GO:45636; positive regulation of melanocyte differentiation
GO:45930; negative regulation of mitotic cell cycle
GO:46671; negative regulation of retinal cell programmed cell death
GO:48041; focal adhesion assembly
GO:48066; developmental pigmentation
GO:48070; regulation of developmental pigmentation
GO:48087; positive regulation of developmental pigmentation
GO:48536; spleen development
GO:48538; thymus development
GO:48545; response to steroid hormone
GO:48546; digestive tract morphogenesis
GO:48589; developmental growth
GO:48599; oocyte development
GO:48743; positive regulation of skeletal muscle fiber development
GO:48753; pigment granule organization
GO:48873; homeostasis of number of cells within a tissue
GO:50790; regulation of catalytic activity
GO:51384; response to glucocorticoid
GO:51726; regulation of cell cycle
GO:71310; cellular response to organic substance
GO:71456; cellular response to hypoxia
GO:72593; reactive oxygen species metabolic process
GO:98609; cell-cell adhesion
GO:2000134; negative regulation of G1/S transition of mitotic cell cycle
GO:2000378; negative regulation of reactive oxygen species metabolic process
Cellular component: GO:16020; membrane
GO:16021; integral component of membrane
GO:5634; nucleus
GO:5737; cytoplasm
GO:5783; endoplasmic reticulum
GO:5789; endoplasmic reticulum membrane
GO:5654; nucleoplasm
GO:5739; mitochondrion
GO:5741; mitochondrial outer membrane
GO:31965; nuclear membrane
GO:32991; protein-containing complex
GO:46930; pore complex
GO:31966; mitochondrial membrane
GO:5829; cytosol
GO:43209; myelin sheath
Function: GO:31625; ubiquitin protein ligase binding
GO:42802; identical protein binding
GO:5515; protein binding
GO:42803; protein homodimerization activity
GO:51434; BH3 domain binding
GO:2020; protease binding
GO:46982; protein heterodimerization activity
GO:43565; sequence-specific DNA binding
GO:140297; DNA-binding transcription factor binding
GO:15267; channel activity
GO:16248; channel inhibitor activity
GO:19903; protein phosphatase binding
GO:51721; protein phosphatase 2A binding
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Homologs of BCL2 in Model Organisms

Danio rerio
bcl2
Mus musculus
Bcl2
Rattus norvegicus
Bcl2

In other databases

GenAge human genes
  • This gene is present as BCL2

External links

OMIM
151430
Ensembl
ENSG00000171791
Entrez Gene
596
UniGene
150749
1000 Genomes
1000 Genomes
HPRD
GenAtlas
BCL2
GeneCards
BCL2