GenAge entry for BCL2 (Homo sapiens)

Gene name (HAGRID: 69)

HGNC symbol: BCL2
Aliases: Bcl-2; PPP1R50
Common name: B-cell CLL/lymphoma 2

Potential relevance to the human ageing process

Main reason for selection: Entry selected based on evidence linking the gene product to a pathway or mechanism linked to ageing
Description: BCL2 is an important suppressor of apoptosis and an oncogene. Apart from cancer, it may be involved in neurodegenerative disorders [447], and dendritic cell longevity in vivo has been reported to be controlled by BCL2 [1110]. BCL2 null mice die by six weeks of age with occurrence of grey hair though otherwise they do not appear to suffer from accelerated ageing [449]. In addition, some researchers have argued that BCL2's role in apoptosis suggests an involvement of BCL2 in ageing [942]. More detailed studies are necessary to investigate this possibility.

Cytogenetic information

Cytogenetic band: 18q21.3
Location: 63,123,346 bp to 63,319,380 bp
Orientation: Minus strand

Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology

Process:

GO:0000209; protein polyubiquitination
GO:0001503; ossification
GO:0001541; ovarian follicle development
GO:0001656; metanephros development
GO:0001658; branching involved in ureteric bud morphogenesis
GO:0001662; behavioral fear response
GO:0001782; B cell homeostasis
GO:0001836; release of cytochrome c from mitochondria
GO:0001952; regulation of cell-matrix adhesion
GO:0002320; lymphoid progenitor cell differentiation
GO:0002326; B cell lineage commitment

And 101 more GO terms

Cellular component:	GO:0005634; nucleus GO:0005737; cytoplasm GO:0005739; mitochondrion GO:0005741; mitochondrial outer membrane GO:0005783; endoplasmic reticulum GO:0005789; endoplasmic reticulum membrane GO:0005829; cytosol GO:0016020; membrane GO:0031965; nuclear membrane GO:0043209; myelin sheath GO:0046930; pore complex
	And 1 more GO terms

Function:

GO:0002020; protease binding
GO:0005515; protein binding
GO:0008134; transcription factor binding
GO:0015267; channel activity
GO:0016248; channel inhibitor activity
GO:0031625; ubiquitin protein ligase binding
GO:0042802; identical protein binding
GO:0042803; protein homodimerization activity
GO:0043565; sequence-specific DNA binding
GO:0046982; protein heterodimerization activity
GO:0051434; BH3 domain binding

And 2 more GO terms

Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge: TP53, IRS1, IRS2, MYC, PPARA, PARP1, BRCA1, PIN1, HIF1A, BCL2, HSP90AA1, UBE2I, PML, BAX, SOD1, HSPA1A, MAPK8, CDK1, PSEN1, PPP1CA, CISD2, BAK1, IKBKB, SQSTM1
STRING interaction network

Retrieve sequences for BCL2

Promoter: Promoter
ORF: ORF
CDS: CDS

Homologs in model organisms

Danio rerio: bcl2
Mus musculus: Bcl2
Rattus norvegicus: Bcl2

In other databases

CellAge

This gene is present as BCL2