Cell Senescence Entries for BMI1

Cell Types
Foreskin fibroblast, Lung fibroblast, Skin fibroblast
Cell Lines
82-6, BJ, WI-38
Cancer Cell?
No
Method
Knockout, Overexpression
Type of senescence
Replicative
Senescence Effect
Inhibits
Primary Reference
Itahana et al. (2003) Control of the replicative life span of human fibroblasts by p16 and the polycomb protein Bmi-1. Mol Cell Biol 23(1)389-401 (PubMed)

BMI1 Gene Information

HGNC symbol
BMI1 
Aliases
PCGF4; RNF51 
Common name
BMI1 proto-oncogene, polycomb ring finger 
Entrez Id
648
Description
This gene encodes a ring finger protein that is major component of the polycomb group complex 1 (PRC1). This complex functions through chromatin remodeling as an essential epigenetic repressor of multiple regulatory genes involved in embryonic development and self-renewal in somatic stem cells. This protein also plays a central role in DNA damage repair. This gene is an oncogene and aberrant expression is associated with numerous cancers and is associated with resistance to certain chemotherapies. A pseudogene of this gene is found on chromosome X. Read-through transcription also exists between this gene and the upstream COMM domain containing 3 (COMMD3) gene. [provided by RefSeq, Sep 2015].

BMI1 Ontologies

Gene Ontology
Process: GO:6325; chromatin organization
GO:122; negative regulation of transcription by RNA polymerase II
GO:30097; hemopoiesis
GO:45814; negative regulation of gene expression, epigenetic
GO:36353; histone H2A-K119 monoubiquitination
GO:48146; positive regulation of fibroblast proliferation
GO:10468; regulation of gene expression
GO:51443; positive regulation of ubiquitin-protein transferase activity
GO:7379; segment specification
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:5829; cytosol
GO:16604; nuclear body
GO:31519; PcG protein complex
GO:5654; nucleoplasm
GO:35102; PRC1 complex
GO:151; ubiquitin ligase complex
Function: GO:46872; metal ion binding
GO:8270; zinc ion binding
GO:5515; protein binding
GO:1990841; promoter-specific chromatin binding
GO:71535; RING-like zinc finger domain binding
Hide GO terms

Homologs of BMI1 in Model Organisms

Danio rerio
bmi1a
Mus musculus
Bmi1
Rattus norvegicus
Bmi1

In other databases

GenAge human genes
  • This gene is present as BMI1

External links

OMIM
164831
Ensembl
ENSG00000168283
Entrez Gene
648
UniGene
731287
1000 Genomes
1000 Genomes
HPRD
GenAtlas
BMI1
GeneCards
BMI1