Cell Senescence Entries for BMI1
BMI1 Gene Information
- HGNC symbol
- BMI1
- Aliases
- PCGF4; RNF51
- Common name
- BMI1 proto-oncogene, polycomb ring finger
- Entrez Id
- 648
- Description
- This gene encodes a ring finger protein that is major component of the polycomb group complex 1 (PRC1). This complex functions through chromatin remodeling as an essential epigenetic repressor of multiple regulatory genes involved in embryonic development and self-renewal in somatic stem cells. This protein also plays a central role in DNA damage repair. This gene is an oncogene and aberrant expression is associated with numerous cancers and is associated with resistance to certain chemotherapies. A pseudogene of this gene is found on chromosome X. Read-through transcription also exists between this gene and the upstream COMM domain containing 3 (COMMD3) gene. [provided by RefSeq, Sep 2015].
BMI1 Ontologies
- Gene Ontology
-
Process: GO:6325; chromatin organization
GO:122; negative regulation of transcription by RNA polymerase II
GO:30097; hemopoiesis
GO:45814; negative regulation of gene expression, epigenetic
GO:36353; histone H2A-K119 monoubiquitination
GO:48146; positive regulation of fibroblast proliferation
GO:10468; regulation of gene expression
GO:51443; positive regulation of ubiquitin-protein transferase activity
GO:7379; segment specification
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:5829; cytosol
GO:16604; nuclear body
GO:31519; PcG protein complex
GO:5654; nucleoplasm
GO:35102; PRC1 complex
GO:151; ubiquitin ligase complex
Hide GO termsFunction: GO:46872; metal ion binding
GO:8270; zinc ion binding
GO:5515; protein binding
GO:1990841; promoter-specific chromatin binding
GO:71535; RING-like zinc finger domain binding
Homologs of BMI1 in Model Organisms
In other databases
- GenAge human genes
- This gene is present as BMI1
External links
- OMIM
- 164831
- Ensembl
- ENSG00000168283
- Entrez Gene
- 648
- UniGene
- 731287
- 1000 Genomes
- 1000 Genomes
- HPRD
- GenAtlas
- BMI1
- GeneCards
- BMI1