GenAge entry for BMI1 (Homo sapiens)

Gene name (HAGRID: 188)

HGNC symbol: BMI1
Aliases: RNF51; PCGF4
Common name: BMI1 proto-oncogene, polycomb ring finger

Potential relevance to the human ageing process

Main reason for selection: Entry selected based on indirect or inconclusive evidence linking the gene product to ageing in humans or in one or more model systems
Description: BMI1 is an oncogene involved in transcriptional regulation by remodelling chromatin. It may also be involved in development. Overexpression of BMI1 in mice results in transformation of axial skeleton [813]. BMI1-null mice show reduced self-renewal of neural stem cells [811], and thus a role for BMI1 in stem cell senescence has been proposed [1402]. Bmi-1 is downregulated in the aging brain [3325]. Additionally, brains of 8 month old Bmi-1 heterozygous knockout mice display mild oxidative stress through significant increases in hydroxy radical and nitrotyrosine compared with wild-type littermates. The hippocampus of these mice has also a high apoptotic percentage and lipofuscin depositions in pyramidal neurons. Behaviorally, the mice show mild spatial memory impairment, suggesting an early onset of age-related brain changes [3582]. It has also been suggested that Bmi-1 is important for the maintenance of redox balance resulting in a protective role against renal tubulointerstitial injury [3583]. Whether BMI1 impacts on human ageing remains to be determined.

Cytogenetic information

Cytogenetic band: 10p11.23
Location: 22,321,210 bp to 22,331,485 bp
Orientation: Plus strand

Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology

Process:

GO:0000122; negative regulation of transcription from RNA polymerase II promoter
GO:0006351; transcription, DNA-templated
GO:0007379; segment specification
GO:0010468; regulation of gene expression
GO:0016569; covalent chromatin modification
GO:0016925; protein sumoylation
GO:0030097; hemopoiesis
GO:0045814; negative regulation of gene expression, epigenetic
GO:0048146; positive regulation of fibroblast proliferation
GO:0051443; positive regulation of ubiquitin-protein transferase activity

Cellular component:

GO:0000151; ubiquitin ligase complex
GO:0005634; nucleus
GO:0005654; nucleoplasm
GO:0005737; cytoplasm
GO:0031519; PcG protein complex
GO:0035102; PRC1 complex

Function:

GO:0005515; protein binding
GO:0008270; zinc ion binding
GO:0071535; RING-like zinc finger domain binding
GO:1990841; promoter-specific chromatin binding

Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge: TP53, ATM, NBN, PARP1, PTEN, CREBBP, TOP2A, UBE2I, EP300, PRKDC, AR, XRCC5, TERF2, AIFM1, HSPA1A, MAPK14, BMI1, H2AFX, DBN1, SOCS2, PYCR1
STRING interaction network

Retrieve sequences for BMI1

ORF: ORF
CDS: CDS

Homologs in model organisms

Danio rerio: bmi1a
Mus musculus: Bmi1
Rattus norvegicus: Bmi1

In other databases

CellAge

This gene is present as BMI1