Cell Senescence Entries for CBS

Cell Types
Aortic endothelial, Umbilical vein endothelial
Cell Lines
HAEC, HUVEC
Cancer Cell?
No
Method
Knockdown, Overexpression
Type of senescence
Replicative
Senescence Effect
Inhibits
Primary Reference
Albertini et al. (2013) Cystathionine beta synthase modulates senescence of human endothelial cells. Aging (Albany NY) 4(10)664-73 (PubMed)

CBS Gene Information

HGNC symbol
CBS 
Aliases
HIP4 
Common name
cystathionine beta-synthase 
Entrez Id
875
Description
The protein encoded by this gene acts as a homotetramer to catalyze the conversion of homocysteine to cystathionine, the first step in the transsulfuration pathway. The encoded protein is allosterically activated by adenosyl-methionine and uses pyridoxal phosphate as a cofactor. Defects in this gene can cause cystathionine beta-synthase deficiency (CBSD), which can lead to homocystinuria. This gene is a major contributor to cellular hydrogen sulfide production. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Feb 2016].

CBS Ontologies

Gene Ontology
Process: GO:8152; metabolic process
GO:8652; cellular amino acid biosynthetic process
GO:6535; cysteine biosynthetic process from serine
GO:50667; homocysteine metabolic process
GO:19344; cysteine biosynthetic process
GO:6565; L-serine catabolic process
GO:6563; L-serine metabolic process
GO:19448; L-cysteine catabolic process
GO:70814; hydrogen sulfide biosynthetic process
GO:19343; cysteine biosynthetic process via cystathionine
GO:42262; DNA protection
GO:43418; homocysteine catabolic process
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:5829; cytosol
Function: GO:46872; metal ion binding
GO:31625; ubiquitin protein ligase binding
GO:16829; lyase activity
GO:42803; protein homodimerization activity
GO:3824; catalytic activity
GO:5515; protein binding
GO:19899; enzyme binding
GO:42802; identical protein binding
GO:20037; heme binding
GO:30170; pyridoxal phosphate binding
GO:70026; nitric oxide binding
GO:72341; modified amino acid binding
GO:4122; cystathionine beta-synthase activity
GO:19825; oxygen binding
GO:50421; nitrite reductase (NO-forming) activity
GO:70025; carbon monoxide binding
GO:1904047; S-adenosyl-L-methionine binding
Hide GO terms

Homologs of CBS in Model Organisms

Caenorhabditis elegans
cysl-4
Danio rerio
cbsa
Drosophila melanogaster
Cbs
Mus musculus
Cbs
Rattus norvegicus
Cbs
Saccharomyces cerevisiae
CYS4
Schizosaccharomyces pombe
cys12

In other databases

GenAge model organism genes
  • A homolog of this gene for Saccharomyces cerevisiae is present as CYS4
  • A homolog of this gene for Drosophila melanogaster is present as Cbs
GenDR gene manipulations
  • A homolog of this gene for Drosophila melanogaster is present as Cbs
CellAge gene expression
  • This gene is present as CBS

External links

OMIM
613381
Ensembl
ENSG00000160200
Entrez Gene
875
UniGene
533013
1000 Genomes
1000 Genomes
HPRD
GenAtlas
CBS
GeneCards
CBS