Cell Senescence Entries for CCN2

Cell Types
Breast cancer, Foreskin fibroblast
Cell Lines
HTERT-BJ1, MDA-MB-231
Cancer Cell?
Yes
Method
Overexpression
Type of senescence
Oncogene-induced
Senescence Effect
Induces
Primary Reference
Capparelli et al. (2012) CTGF drives autophagy, glycolysis and senescence in cancer-associated fibroblasts via HIF1 activation, metabolically promoting tumor growth. Cell Cycle 11(12)2272-84 (PubMed)

CCN2 Gene Information

HGNC symbol
CCN2 
Aliases
CTGF; IGFBP8 
Common name
cellular communication network factor 2 
Entrez Id
1490
Description
The protein encoded by this gene is a mitogen that is secreted by vascular endothelial cells. The encoded protein plays a role in chondrocyte proliferation and differentiation, cell adhesion in many cell types, and is related to platelet-derived growth factor. Certain polymorphisms in this gene have been linked with a higher incidence of systemic sclerosis. [provided by RefSeq, Nov 2009].

CCN2 Ontologies

Gene Ontology
Process: GO:7165; signal transduction
GO:7155; cell adhesion
GO:71897; DNA biosynthetic process
GO:9611; response to wounding
GO:46330; positive regulation of JNK cascade
GO:70374; positive regulation of ERK1 and ERK2 cascade
GO:60548; negative regulation of cell death
GO:51496; positive regulation of stress fiber assembly
GO:8544; epidermis development
GO:45597; positive regulation of cell differentiation
GO:1502; cartilage condensation
GO:1503; ossification
GO:1525; angiogenesis
GO:1894; tissue homeostasis
GO:1934; positive regulation of protein phosphorylation
GO:7160; cell-matrix adhesion
GO:7229; integrin-mediated signaling pathway
GO:7568; aging
GO:8284; positive regulation of cell population proliferation
GO:8543; fibroblast growth factor receptor signaling pathway
GO:9749; response to glucose
GO:10628; positive regulation of gene expression
GO:10629; negative regulation of gene expression
GO:10942; positive regulation of cell death
GO:14070; response to organic cyclic compound
GO:16477; cell migration
GO:30154; cell differentiation
GO:30324; lung development
GO:32330; regulation of chondrocyte differentiation
GO:32355; response to estradiol
GO:32967; positive regulation of collagen biosynthetic process
GO:34059; response to anoxia
GO:35556; intracellular signal transduction
GO:35988; chondrocyte proliferation
GO:43200; response to amino acid
GO:43280; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:43434; response to peptide hormone
GO:50867; positive regulation of cell activation
GO:51385; response to mineralocorticoid
GO:60401; cytosolic calcium ion transport
GO:60452; positive regulation of cardiac muscle contraction
GO:61448; connective tissue development
GO:70278; extracellular matrix constituent secretion
GO:70318; positive regulation of G0 to G1 transition
GO:70542; response to fatty acid
GO:72593; reactive oxygen species metabolic process
Cellular component: GO:5576; extracellular region
GO:31012; extracellular matrix
GO:62023; collagen-containing extracellular matrix
GO:5886; plasma membrane
GO:5615; extracellular space
GO:5801; cis-Golgi network
GO:5829; cytosol
GO:5938; cell cortex
GO:48471; perinuclear region of cytoplasm
Function: GO:5515; protein binding
GO:8201; heparin binding
GO:8022; protein C-terminus binding
GO:5178; integrin binding
GO:5520; insulin-like growth factor binding
GO:1968; fibronectin binding
GO:8083; growth factor activity
Hide GO terms

Homologs of CCN2 in Model Organisms

Danio rerio
ctgfa
Mus musculus
Ctgf
Rattus norvegicus
Ctgf

In other databases

GenAge human genes
  • This gene is present as CTGF
GenDR gene expression
  • A homolog of this gene for Mus musculus is present as Ctgf
CellAge gene expression
  • This gene is present as CTGF

External links

OMIM
121009
Ensembl
ENSG00000118523
Entrez Gene
1490
UniGene
410037
1000 Genomes
1000 Genomes
HPRD
GenAtlas
CCN2
GeneCards
CCN2