GenAge entry for CTGF (Homo sapiens)

Gene name (HAGRID: 206)

HGNC symbol: CTGF
Aliases: IGFBP8; CCN2
Common name: connective tissue growth factor

Potential relevance to the human ageing process

Main reason for selection: Entry selected based on indirect or inconclusive evidence linking the gene product to ageing in humans or in one or more model systems
Description: CTGF is an important growth factor secreted by vascular endothelial cells. Overexpression of CTGF in mice resulted in dwarfism and decreased bone density [884]. Age-related upregulation of CTGF in senescent cells and in rat liver has also been reported [1737]. Further studies are necessary to determined whether CTGF influences human ageing.

Cytogenetic information

Cytogenetic band: 6q23.1
Location: 131,948,177 bp to 131,951,378 bp
Orientation: Minus strand

Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology

Process:	GO:0001502; cartilage condensation GO:0001503; ossification GO:0001525; angiogenesis GO:0001558; regulation of cell growth GO:0001894; tissue homeostasis GO:0006367; transcription initiation from RNA polymerase II promoter GO:0007155; cell adhesion GO:0007160; cell-matrix adhesion GO:0007229; integrin-mediated signaling pathway GO:0007267; cell-cell signaling GO:0007568; aging
	And 34 more GO terms

Cellular component:

GO:0005576; extracellular region
GO:0005578; proteinaceous extracellular matrix
GO:0005615; extracellular space
GO:0005794; Golgi apparatus
GO:0005801; cis-Golgi network
GO:0005829; cytosol
GO:0005886; plasma membrane
GO:0005938; cell cortex
GO:0043231; intracellular membrane-bounded organelle
GO:0048471; perinuclear region of cytoplasm

Function:

GO:0001968; fibronectin binding
GO:0005178; integrin binding
GO:0005515; protein binding
GO:0005520; insulin-like growth factor binding
GO:0008022; protein C-terminus binding
GO:0008083; growth factor activity
GO:0008201; heparin binding

Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge: EGFR, VEGFA
STRING interaction network

Retrieve sequences for CTGF

Promoter: Promoter
ORF: ORF
CDS: CDS

Homologs in model organisms

Danio rerio: ctgfa
Mus musculus: Ctgf
Rattus norvegicus: Ctgf

In other databases

GenDR gene expression

A homolog of this gene for Mus musculus is present as Ctgf

CellAge

This gene is present as CCN2

CellAge gene expression

This gene is present as CTGF