Cell Senescence Entries for FOXO4

Cell Types
Osteosarcoma, Thyroid gland cancer
Cell Lines
A14, U2OS
Cancer Cell?
Yes
Method
Overexpression
Type of senescence
Oncogene-induced
Senescence Effect
Induces
Primary Reference
de Keizer et al. (2010) Activation of forkhead box O transcription factors by oncogenic BRAF promotes p21cip1-dependent senescence. Cancer Res 70(21)8526-36 (PubMed)

FOXO4 Gene Information

HGNC symbol
FOXO4 
Aliases
AFX1; MLLT7 
Common name
forkhead box O4 
Entrez Id
4303
Description
This gene encodes a member of the O class of winged helix/forkhead transcription factor family. Proteins encoded by this class are regulated by factors involved in growth and differentiation indicating they play a role in these processes. A translocation involving this gene on chromosome X and the homolog of the Drosophila trithorax gene, encoding a DNA binding protein, located on chromosome 11 is associated with leukemia. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2010].

FOXO4 Ontologies

Gene Ontology
Process: GO:7049; cell cycle
GO:6355; regulation of transcription, DNA-templated
GO:30154; cell differentiation
GO:7517; muscle organ development
GO:6357; regulation of transcription by RNA polymerase II
GO:8285; negative regulation of cell population proliferation
GO:48863; stem cell differentiation
GO:45944; positive regulation of transcription by RNA polymerase II
GO:16525; negative regulation of angiogenesis
GO:8286; insulin receptor signaling pathway
GO:51151; negative regulation of smooth muscle cell differentiation
GO:70317; negative regulation of G0 to G1 transition
GO:7095; mitotic G2 DNA damage checkpoint signaling
GO:7568; aging
GO:14911; positive regulation of smooth muscle cell migration
GO:31667; response to nutrient levels
GO:45893; positive regulation of transcription, DNA-templated
GO:1990785; response to water-immersion restraint stress
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:16607; nuclear speck
GO:5829; cytosol
GO:785; chromatin
GO:5654; nucleoplasm
Function: GO:3677; DNA binding
GO:3700; DNA-binding transcription factor activity
GO:43565; sequence-specific DNA binding
GO:5515; protein binding
GO:19899; enzyme binding
GO:42802; identical protein binding
GO:981; DNA-binding transcription factor activity, RNA polymerase II-specific
GO:978; RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:140297; DNA-binding transcription factor binding
GO:1990837; sequence-specific double-stranded DNA binding
GO:1228; DNA-binding transcription activator activity, RNA polymerase II-specific
GO:8013; beta-catenin binding
GO:1990841; promoter-specific chromatin binding
Hide GO terms

Homologs of FOXO4 in Model Organisms

Danio rerio
LOC563719
Drosophila melanogaster
foxo
Mus musculus
Foxo4
Rattus norvegicus
Foxo4
Saccharomyces cerevisiae
FHL1
Schizosaccharomyces pombe
sep1

In other databases

GenAge model organism genes
  • A homolog of this gene for Drosophila melanogaster is present as foxo
GenAge human genes
  • This gene is present as FOXO4
GenDR gene manipulations
  • A homolog of this gene for Drosophila melanogaster is present as foxo
LongevityMap
  • This gene is present as FOXO4

External links

OMIM
300033
Ensembl
ENSG00000184481
Entrez Gene
4303
UniGene
584654
1000 Genomes
1000 Genomes
HPRD
GenAtlas
FOXO4
GeneCards
FOXO4