The HDAC1 gene and its putative association with human ageing

Cell Senescence Entries for HDAC1

Cell Types: Cervical cancer
Cell Lines: HeLa
Cancer Cell?: Yes
Method: Overexpression
Type of senescence: Unclear
Senescence Effect: Induces
Primary Reference: Chuang et al. (2011) Overexpression of HDAC1 induces cellular senescence by Sp1/PP2A/pRb pathway. Biochem Biophys Res Commun 407(3)587-92 (PubMed)

HDAC1 Gene Information

HGNC symbol: HDAC1
Aliases: GON-10; HD1; KDAC1; RPD3L1
Common name: histone deacetylase 1
Entrez Id: 3065
Description: Histone acetylation and deacetylation, catalyzed by multisubunit complexes, play a key role in the regulation of eukaryotic gene expression. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex. It also interacts with retinoblastoma tumor-suppressor protein and this complex is a key element in the control of cell proliferation and differentiation. Together with metastasis-associated protein-2, it deacetylates p53 and modulates its effect on cell growth and apoptosis. [provided by RefSeq, Jul 2008].

HDAC1 Ontologies

Gene Ontology

Process:

GO:10628; positive regulation of gene expression
GO:43066; negative regulation of apoptotic process
GO:45892; negative regulation of transcription, DNA-templated
GO:6325; chromatin organization
GO:6476; protein deacetylation
GO:16575; histone deacetylation
GO:122; negative regulation of transcription by RNA polymerase II
GO:48511; rhythmic process
GO:32922; circadian regulation of gene expression
GO:6357; regulation of transcription by RNA polymerase II
GO:6338; chromatin remodeling
GO:8284; positive regulation of cell population proliferation
GO:45944; positive regulation of transcription by RNA polymerase II
GO:45893; positive regulation of transcription, DNA-templated
GO:42733; embryonic digit morphogenesis
GO:90090; negative regulation of canonical Wnt signaling pathway
GO:60766; negative regulation of androgen receptor signaling pathway
GO:2000273; positive regulation of signaling receptor activity
GO:36120; cellular response to platelet-derived growth factor stimulus
GO:48661; positive regulation of smooth muscle cell proliferation
GO:43922; negative regulation by host of viral transcription
GO:10629; negative regulation of gene expression
GO:42475; odontogenesis of dentin-containing tooth
GO:70932; histone H3 deacetylation
GO:70933; histone H4 deacetylation
GO:6346; DNA methylation-dependent heterochromatin assembly
GO:7492; endoderm development
GO:7623; circadian rhythm
GO:9913; epidermal cell differentiation
GO:21766; hippocampus development
GO:30182; neuron differentiation
GO:43124; negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:48714; positive regulation of oligodendrocyte differentiation
GO:52548; regulation of endopeptidase activity
GO:60789; hair follicle placode formation
GO:61029; eyelid development in camera-type eye
GO:61198; fungiform papilla formation
GO:1900221; regulation of amyloid-beta clearance
GO:2001243; negative regulation of intrinsic apoptotic signaling pathway
GO:30336; negative regulation of cell migration
GO:1902459; positive regulation of stem cell population maintenance
GO:30512; negative regulation of transforming growth factor beta receptor signaling pathway
GO:1902455; negative regulation of stem cell population maintenance
GO:42659; regulation of cell fate specification
GO:2000736; regulation of stem cell differentiation

Cellular component:

GO:5634; nucleus
GO:5737; cytoplasm
GO:32991; protein-containing complex
GO:5654; nucleoplasm
GO:5829; cytosol
GO:785; chromatin
GO:118; histone deacetylase complex
GO:16581; NuRD complex
GO:16580; Sin3 complex
GO:792; heterochromatin
GO:5667; transcription regulator complex
GO:17053; transcription repressor complex
GO:43025; neuronal cell body

Function:

GO:5515; protein binding
GO:46872; metal ion binding
GO:16787; hydrolase activity
GO:19899; enzyme binding
GO:978; RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:4407; histone deacetylase activity
GO:42826; histone deacetylase binding
GO:140297; DNA-binding transcription factor binding
GO:19213; deacetylase activity
GO:61629; RNA polymerase II-specific DNA-binding transcription factor binding
GO:3714; transcription corepressor activity
GO:2039; p53 binding
GO:1222; transcription corepressor binding
GO:33558; protein deacetylase activity
GO:51059; NF-kappaB binding
GO:31492; nucleosomal DNA binding
GO:1046; core promoter sequence-specific DNA binding
GO:979; RNA polymerase II core promoter sequence-specific DNA binding
GO:47485; protein N-terminus binding
GO:976; transcription cis-regulatory region binding
GO:3677; DNA binding
GO:3682; chromatin binding
GO:35851; Krueppel-associated box domain binding
GO:70888; E-box binding
GO:1990841; promoter-specific chromatin binding

Hide GO terms

Homologs of HDAC1 in Model Organisms

Danio rerio: hdac1
Drosophila melanogaster: Rpd3
Mus musculus: Hdac1
Rattus norvegicus: Hdac1
Saccharomyces cerevisiae: RPD3

In other databases

GenAge model organism genes

A homolog of this gene for Saccharomyces cerevisiae is present as RPD3
A homolog of this gene for Drosophila melanogaster is present as Rpd3

GenAge human genes

This gene is present as HDAC1

GenDR gene manipulations

A homolog of this gene for Drosophila melanogaster is present as Rpd3
A homolog of this gene for Saccharomyces cerevisiae is present as RPD3

Cell Senescence Entries for HDAC1

HDAC1 Gene Information

HDAC1 Ontologies

Homologs of HDAC1 in Model Organisms

In other databases

External links