Cell Senescence Entries for HSPA9
- Cell Types
- Breast cancer, Osteosarcoma
- Cell Lines
- MCF-7, U2OS
- Cancer Cell?
- Yes
- Method
- Overexpression
- Type of senescence
- Stress-induced
- Senescence Effect
- Induces
- Primary Reference
- Deocaris et al. (2007) Mortalin sensitizes human cancer cells to MKT-077-induced senescence. Cancer Lett 252(2)259-69 (PubMed)
HSPA9 Gene Information
- HGNC symbol
- HSPA9
- Aliases
- GRP75; HSPA9B; mot-2; mthsp75; PBP74
- Common name
- heat shock protein family A (Hsp70) member 9
- Entrez Id
- 3313
- Description
- This gene encodes a member of the heat shock protein 70 gene family. The encoded protein is primarily localized to the mitochondria but is also found in the endoplasmic reticulum, plasma membrane and cytoplasmic vesicles. This protein is a heat-shock cognate protein. This protein plays a role in cell proliferation, stress response and maintenance of the mitochondria. A pseudogene of this gene is found on chromosome 2.[provided by RefSeq, May 2010].
HSPA9 Ontologies
- Gene Ontology
-
Process: GO:6457; protein folding
GO:43066; negative regulation of apoptotic process
GO:16226; iron-sulfur cluster assembly
GO:30218; erythrocyte differentiation
GO:6611; protein export from nucleus
GO:1902037; negative regulation of hematopoietic stem cell differentiation
GO:1903707; negative regulation of hemopoiesis
GO:7007; inner mitochondrial membrane organization
GO:51085; chaperone cofactor-dependent protein refolding
GO:45646; regulation of erythrocyte differentiation
GO:34620; cellular response to unfolded protein
GO:42026; protein refolding
GO:45647; negative regulation of erythrocyte differentiation
GO:6886; intracellular protein transport
Cellular component: GO:5634; nucleus
GO:5739; mitochondrion
GO:5925; focal adhesion
GO:5730; nucleolus
GO:5737; cytoplasm
GO:5759; mitochondrial matrix
GO:70062; extracellular exosome
GO:5743; mitochondrial inner membrane
GO:42645; mitochondrial nucleoid
GO:1401; SAM complex
GO:140275; MIB complex
GO:5744; TIM23 mitochondrial import inner membrane translocase complex
Hide GO termsFunction: GO:166; nucleotide binding
GO:5524; ATP binding
GO:16887; ATP hydrolysis activity
GO:51082; unfolded protein binding
GO:3723; RNA binding
GO:5515; protein binding
GO:19899; enzyme binding
GO:31625; ubiquitin protein ligase binding
GO:44183; protein folding chaperone
GO:31072; heat shock protein binding
GO:51787; misfolded protein binding
Homologs of HSPA9 in Model Organisms
- Caenorhabditis elegans
- hsp-6
- Danio rerio
- hspa9
- Drosophila melanogaster
- Hsc70-5
- Mus musculus
- Hspa9
- Rattus norvegicus
- Hspa9
- Saccharomyces cerevisiae
- ECM10
- Schizosaccharomyces pombe
- ssp1
In other databases
- GenAge model organism genes
- A homolog of this gene for Caenorhabditis elegans is present as hsp-6
- GenAge human genes
- This gene is present as HSPA9
External links
- OMIM
- 600548
- Ensembl
- ENSG00000113013
- Entrez Gene
- 3313
- UniGene
- 184233
- 1000 Genomes
- 1000 Genomes
- HPRD
- GenAtlas
- HSPA9
- GeneCards
- HSPA9