GenAge entry for HSPA9 (Homo sapiens)
Gene name (HAGRID: 152)
- HGNC symbol
- HSPA9
- Aliases
- GRP75; PBP74; mot-2; mthsp75; HSPA9B
- Common name
- heat shock 70kDa protein 9 (mortalin)
Potential relevance to the human ageing process
- Main reason for selection
- Entry selected based on evidence directly linking the gene product to ageing in a non-mammalian animal model
- Description
HSPA9 appears to be involved in apoptosis and maybe cellular proliferation. It could also be a molecular chaperone. Roundworms with extra copies of Hsp70F, a HSPA9 homologue, live about 40% longer than controls [904]. A role for HSPA9 in human ageing has not been established.
Cytogenetic information
- Cytogenetic band
- 5q31.1
- Location
- 138,554,882 bp to 138,575,629 bp
- Orientation
- Minus strand
Protein information
- Gene Ontology
-
Process: GO:0006457; protein folding
GO:0006611; protein export from nucleus
GO:0030218; erythrocyte differentiation
GO:0043066; negative regulation of apoptotic process
GO:0045647; negative regulation of erythrocyte differentiation
GO:1902037; negative regulation of hematopoietic stem cell differentiation
Cellular component: GO:0005730; nucleolus
GO:0005737; cytoplasm
GO:0005739; mitochondrion
GO:0005925; focal adhesion
GO:0031012; extracellular matrix
GO:0042645; mitochondrial nucleoid
GO:0043209; myelin sheath
GO:0070062; extracellular exosome
Function: GO:0005515; protein binding
GO:0005524; ATP binding
GO:0031625; ubiquitin protein ligase binding
GO:0044822; poly(A) RNA binding
GO:0051082; unfolded protein binding
Protein interactions and network
- Protein-protein interacting partners in GenAge
- SHC1, TP53, AKT1, EGFR, HSP90AA1, GRB2, SOD1, APP, SIRT1, HSPD1, SP1, EEF1A1, HSPA8, H2AFX, CDKN2A, SIRT7, SIRT3, TP73, CDKN1A, SPRTN
- STRING interaction network
Retrieve sequences for HSPA9
Homologs in model organisms
- Caenorhabditis elegans
- hsp-6
- Danio rerio
- hspa9
- Drosophila melanogaster
- Hsc70-5
- Mus musculus
- Hspa9
- Rattus norvegicus
- Hspa9
- Saccharomyces cerevisiae
- ECM10
- Schizosaccharomyces pombe
- ssp1
In other databases
- GenAge model organism genes
- A homolog of this gene for Caenorhabditis elegans is present as hsp-6
- CellAge
- This gene is present as HSPA9
Selected references
External links
- EPD
- HS_HSPA9B_1
- ORF Accession
- NM_004134
- CDS Accession
- NP_004125
- OMIM
- 600548
- HPRD
- 02770
- Ensembl
- HSPA9
- UniProt/Swiss-Prot
- GRP75_HUMAN
- GeneCards
- HSPA9
- Entrez Gene
- 3313
- UniGene
- 184233
- GenAtlas
- HSPA9
- Internet
- Search Google