Cell Senescence Entries for MAP2K7

Cell Types
Embryonic kidney, Lung fibroblast
Cell Lines
HEK293T, IMR-90, MRC-5
Cancer Cell?
No
Method
Overexpression
Type of senescence
Unclear
Senescence Effect
Induces
Primary Reference
Ferrand et al. (2016) Screening of a kinase library reveals novel pro-senescence kinases and their common NF-κB-dependent transcriptional program. Aging (Albany NY) 7(11)986-1003 (PubMed)

MAP2K7 Gene Information

HGNC symbol
MAP2K7 
Aliases
Jnkk2; MKK7; PRKMK7 
Common name
mitogen-activated protein kinase kinase 7 
Entrez Id
5609
Description
The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically activates MAPK8/JNK1 and MAPK9/JNK2, and this kinase itself is phosphorylated and activated by MAP kinase kinase kinases including MAP3K1/MEKK1, MAP3K2/MEKK2,MAP3K3/MEKK5, and MAP4K2/GCK. This kinase is involved in the signal transduction mediating the cell responses to proinflammatory cytokines, and environmental stresses. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014].

MAP2K7 Ontologies

Gene Ontology
Process: GO:6468; protein phosphorylation
GO:16310; phosphorylation
GO:6915; apoptotic process
GO:18108; peptidyl-tyrosine phosphorylation
GO:45893; positive regulation of transcription, DNA-templated
GO:70374; positive regulation of ERK1 and ERK2 cascade
GO:7165; signal transduction
GO:9411; response to UV
GO:43507; positive regulation of JUN kinase activity
GO:165; MAPK cascade
GO:6970; response to osmotic stress
GO:7254; JNK cascade
GO:9408; response to heat
GO:32212; positive regulation of telomere maintenance via telomerase
GO:34612; response to tumor necrosis factor
GO:38095; Fc-epsilon receptor signaling pathway
GO:51403; stress-activated MAPK cascade
GO:51973; positive regulation of telomerase activity
GO:90398; cellular senescence
GO:1904355; positive regulation of telomere capping
GO:1934; positive regulation of protein phosphorylation
GO:43525; positive regulation of neuron apoptotic process
GO:46330; positive regulation of JNK cascade
GO:72709; cellular response to sorbitol
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:5829; cytosol
Function: GO:46872; metal ion binding
GO:166; nucleotide binding
GO:4672; protein kinase activity
GO:4674; protein serine/threonine kinase activity
GO:4712; protein serine/threonine/tyrosine kinase activity
GO:5524; ATP binding
GO:16301; kinase activity
GO:16740; transferase activity
GO:106310; protein serine kinase activity
GO:4713; protein tyrosine kinase activity
GO:5515; protein binding
GO:287; magnesium ion binding
GO:19901; protein kinase binding
GO:19899; enzyme binding
GO:4708; MAP kinase kinase activity
GO:8545; JUN kinase kinase activity
GO:19903; protein phosphatase binding
GO:8022; protein C-terminus binding
GO:31435; mitogen-activated protein kinase kinase kinase binding
Hide GO terms

Homologs of MAP2K7 in Model Organisms

Caenorhabditis elegans
mek-1
Danio rerio
map2k7
Mus musculus
Map2k7
Rattus norvegicus
Map2k7

In other databases

GenDR gene manipulations
  • A homolog of this gene for Caenorhabditis elegans is present as mek-1

External links

OMIM
603014
Ensembl
ENSG00000076984
Entrez Gene
5609
UniGene
531754
1000 Genomes
1000 Genomes
HPRD
GenAtlas
MAP2K7
GeneCards
MAP2K7