The SIRT2 gene and its putative association with human ageing

Cell Types

Foreskin fibroblast

Cell Lines

BJ

Cancer Cell?

No

Method

Knockdown

Type of senescence

Unclear

Senescence Effect

Inhibits

Primary Reference

Kilic Eren et al. (2016) Resveratrol Induced Premature Senescence Is Associated with DNA Damage Mediated SIRT1 and SIRT2 Down-Regulation. PLoS One 10(4)e0124837 (PubMed)

HGNC symbol

SIRT2

Aliases

SIR2L

Common name

sirtuin 2

Entrez Id

22933

Description

This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Several transcript variants are resulted from alternative splicing of this gene. [provided by RefSeq, Jul 2010].

Gene Ontology

Process:

GO:7049; cell cycle
GO:45892; negative regulation of transcription, DNA-templated
GO:51301; cell division
GO:30154; cell differentiation
GO:6476; protein deacetylation
GO:16575; histone deacetylation
GO:45944; positive regulation of transcription by RNA polymerase II
GO:6914; autophagy
GO:122; negative regulation of transcription by RNA polymerase II
GO:2376; immune system process
GO:45087; innate immune response
GO:7399; nervous system development
GO:51321; meiotic cell cycle
GO:51781; positive regulation of cell division
GO:43161; proteasome-mediated ubiquitin-dependent protein catabolic process
GO:51726; regulation of cell cycle
GO:8285; negative regulation of cell population proliferation
GO:45836; positive regulation of meiotic nuclear division
GO:71219; cellular response to molecule of bacterial origin
GO:21762; substantia nigra development
GO:34599; cellular response to oxidative stress
GO:45599; negative regulation of fat cell differentiation
GO:51775; response to redox state
GO:14065; phosphatidylinositol 3-kinase signaling
GO:42177; negative regulation of protein catabolic process
GO:31507; heterochromatin assembly
GO:70932; histone H3 deacetylation
GO:71456; cellular response to hypoxia
GO:183; rDNA heterochromatin assembly
GO:1900425; negative regulation of defense response to bacterium
GO:10507; negative regulation of autophagy
GO:42325; regulation of phosphorylation
GO:43388; positive regulation of DNA binding
GO:32436; positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:31641; regulation of myelination
GO:6471; protein ADP-ribosylation
GO:43491; protein kinase B signaling
GO:2000378; negative regulation of reactive oxygen species metabolic process
GO:35729; cellular response to hepatocyte growth factor stimulus
GO:7084; mitotic nuclear membrane reassembly
GO:44242; cellular lipid catabolic process
GO:71872; cellular response to epinephrine stimulus
GO:61428; negative regulation of transcription from RNA polymerase II promoter in response to hypoxia
GO:1900119; positive regulation of execution phase of apoptosis
GO:7096; regulation of exit from mitosis
GO:22011; myelination in peripheral nervous system
GO:1900195; positive regulation of oocyte maturation
GO:10801; negative regulation of peptidyl-threonine phosphorylation
GO:70933; histone H4 deacetylation
GO:31509; subtelomeric heterochromatin assembly
GO:34983; peptidyl-lysine deacetylation
GO:45843; negative regulation of striated muscle tissue development
GO:48012; hepatocyte growth factor receptor signaling pathway
GO:51987; positive regulation of attachment of spindle microtubules to kinetochore
GO:61433; cellular response to caloric restriction
GO:70446; negative regulation of oligodendrocyte progenitor proliferation
GO:90042; tubulin deacetylation
GO:2000777; positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxia
GO:45598; regulation of fat cell differentiation
GO:1900226; negative regulation of NLRP3 inflammasome complex assembly

Cellular component:

GO:5634; nucleus
GO:5737; cytoplasm
GO:16020; membrane
GO:5730; nucleolus
GO:5829; cytosol
GO:5886; plasma membrane
GO:5814; centriole
GO:5856; cytoskeleton
GO:5694; chromosome
GO:42995; cell projection
GO:5874; microtubule
GO:48471; perinuclear region of cytoplasm
GO:43209; myelin sheath
GO:43204; perikaryon
GO:5815; microtubule organizing center
GO:5819; spindle
GO:30496; midbody
GO:5813; centrosome
GO:33010; paranodal junction
GO:30426; growth cone
GO:792; heterochromatin
GO:781; chromosome, telomeric region
GO:72686; mitotic spindle
GO:5677; chromatin silencing complex
GO:72687; meiotic spindle
GO:97386; glial cell projection
GO:33270; paranode region of axon
GO:44224; juxtaparanode region of axon
GO:43220; Schmidt-Lanterman incisure
GO:43219; lateral loop
GO:5739; mitochondrion

Function:

GO:70403; NAD+ binding
GO:46872; metal ion binding
GO:16740; transferase activity
GO:8270; zinc ion binding
GO:34979; NAD-dependent protein deacetylase activity
GO:17136; NAD-dependent histone deacetylase activity
GO:51287; NAD binding
GO:5515; protein binding
GO:43130; ubiquitin binding
GO:4407; histone deacetylase activity
GO:42826; histone deacetylase binding
GO:140297; DNA-binding transcription factor binding
GO:3682; chromatin binding
GO:33558; protein deacetylase activity
GO:3950; NAD+ ADP-ribosyltransferase activity
GO:35035; histone acetyltransferase binding
GO:42903; tubulin deacetylase activity
GO:46970; NAD-dependent histone deacetylase activity (H4-K16 specific)

Hide GO terms

Danio rerio

sirt2

Drosophila melanogaster

Sirt2

Mus musculus

Sirt2

Rattus norvegicus

Sirt2

Saccharomyces cerevisiae

HST2

Schizosaccharomyces pombe