Cell Senescence Entries for ATG5

Cell Types
Foreskin fibroblast, Lung fibroblast
Cell Lines
BJ, IMR-90
Cancer Cell?
No
Method
Knockdown
Type of senescence
Oncogene-induced
Senescence Effect
Inhibits
Primary Reference
Young et al. (2009) Autophagy mediates the mitotic senescence transition. Genes Dev 23(7)798-803 (PubMed)

ATG5 Gene Information

HGNC symbol
ATG5 
Aliases
APG5; APG5L; ASP; hAPG5 
Common name
autophagy related 5 
Entrez Id
9474
Description
The protein encoded by this gene, in combination with autophagy protein 12, functions as an E1-like activating enzyme in a ubiquitin-like conjugating system. The encoded protein is involved in several cellular processes, including autophagic vesicle formation, mitochondrial quality control after oxidative damage, negative regulation of the innate antiviral immune response, lymphocyte development and proliferation, MHC II antigen presentation, adipocyte differentiation, and apoptosis. Several transcript variants encoding different protein isoforms have been found for this gene. [provided by RefSeq, Sep 2015].

ATG5 Ontologies

Gene Ontology
Process: GO:6914; autophagy
GO:16236; macroautophagy
GO:6915; apoptotic process
GO:45; autophagosome assembly
GO:2376; immune system process
GO:43687; post-translational protein modification
GO:1902017; regulation of cilium assembly
GO:422; autophagy of mitochondrion
GO:6995; cellular response to nitrogen starvation
GO:60548; negative regulation of cell death
GO:6497; protein lipidation
And 34 more GO terms
Cellular component: GO:5737; cytoplasm
GO:16020; membrane
GO:34045; phagophore assembly site membrane
GO:5930; axoneme
GO:5829; cytosol
GO:30670; phagocytic vesicle membrane
GO:5776; autophagosome
GO:34274; Atg12-Atg5-Atg16 complex
GO:1990234; transferase complex
GO:32991; protein-containing complex
GO:30424; axon
And 2 more GO terms
Function: GO:5515; protein binding
Show all GO terms

Homologs of ATG5 in Model Organisms

Caenorhabditis elegans
atg-5
Danio rerio
atg5
Drosophila melanogaster
Atg5
Mus musculus
Atg5
Rattus norvegicus
Atg5
Saccharomyces cerevisiae
ATG5
Schizosaccharomyces pombe
atg5

In other databases

GenAge model organism genes
  • A homolog of this gene for Caenorhabditis elegans is present as atg-5
  • A homolog of this gene for Saccharomyces cerevisiae is present as ATG5
  • A homolog of this gene for Mus musculus is present as Atg5
GenDR gene manipulations
  • A homolog of this gene for Saccharomyces cerevisiae is present as ATG5

External links

OMIM
604261
Ensembl
ENSG00000057663
Entrez Gene
9474
UniGene
486063
1000 Genomes
1000 Genomes
HPRD
GenAtlas
ATG5
GeneCards
ATG5