Cell Senescence Entries for CCN2

Cell Types
Breast cancer, Foreskin fibroblast
Cell Lines
HTERT-BJ1, MDA-MB-231
Cancer Cell?
Yes
Method
Overexpression
Type of senescence
Oncogene-induced
Senescence Effect
Induces
Primary Reference
Capparelli et al. (2012) CTGF drives autophagy, glycolysis and senescence in cancer-associated fibroblasts via HIF1 activation, metabolically promoting tumor growth. Cell Cycle 11(12)2272-84 (PubMed)

CCN2 Gene Information

HGNC symbol
CCN2 
Aliases
CTGF; IGFBP8 
Common name
cellular communication network factor 2 
Entrez Id
1490
Description
The protein encoded by this gene is a mitogen that is secreted by vascular endothelial cells. The encoded protein plays a role in chondrocyte proliferation and differentiation, cell adhesion in many cell types, and is related to platelet-derived growth factor. Certain polymorphisms in this gene have been linked with a higher incidence of systemic sclerosis. [provided by RefSeq, Nov 2009].

CCN2 Ontologies

Gene Ontology
Process: GO:7165; signal transduction
GO:7155; cell adhesion
GO:71897; DNA biosynthetic process
GO:9611; response to wounding
GO:46330; positive regulation of JNK cascade
GO:70374; positive regulation of ERK1 and ERK2 cascade
GO:60548; negative regulation of cell death
GO:51496; positive regulation of stress fiber assembly
GO:8544; epidermis development
GO:45597; positive regulation of cell differentiation
GO:1502; cartilage condensation
And 36 more GO terms
Cellular component: GO:5576; extracellular region
GO:31012; extracellular matrix
GO:62023; collagen-containing extracellular matrix
GO:5886; plasma membrane
GO:5615; extracellular space
GO:5801; cis-Golgi network
GO:5829; cytosol
GO:5938; cell cortex
GO:48471; perinuclear region of cytoplasm
Function: GO:5515; protein binding
GO:8201; heparin binding
GO:8022; protein C-terminus binding
GO:5178; integrin binding
GO:5520; insulin-like growth factor binding
GO:1968; fibronectin binding
GO:8083; growth factor activity
Show all GO terms

Homologs of CCN2 in Model Organisms

Danio rerio
ctgfa
Mus musculus
Ctgf
Rattus norvegicus
Ctgf

In other databases

GenAge human genes
  • This gene is present as CTGF
GenDR gene expression
  • A homolog of this gene for Mus musculus is present as Ctgf
CellAge gene expression
  • This gene is present as CTGF

External links

OMIM
121009
Ensembl
ENSG00000118523
Entrez Gene
1490
UniGene
410037
1000 Genomes
1000 Genomes
HPRD
GenAtlas
CCN2
GeneCards
CCN2