Cell Senescence Entries for HDAC1

Cell Types
Cervical cancer
Cell Lines
HeLa
Cancer Cell?
Yes
Method
Overexpression
Type of senescence
Unclear
Senescence Effect
Induces
Primary Reference
Chuang et al. (2011) Overexpression of HDAC1 induces cellular senescence by Sp1/PP2A/pRb pathway. Biochem Biophys Res Commun 407(3)587-92 (PubMed)

HDAC1 Gene Information

HGNC symbol
HDAC1 
Aliases
GON-10; HD1; KDAC1; RPD3L1 
Common name
histone deacetylase 1 
Entrez Id
3065
Description
Histone acetylation and deacetylation, catalyzed by multisubunit complexes, play a key role in the regulation of eukaryotic gene expression. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex. It also interacts with retinoblastoma tumor-suppressor protein and this complex is a key element in the control of cell proliferation and differentiation. Together with metastasis-associated protein-2, it deacetylates p53 and modulates its effect on cell growth and apoptosis. [provided by RefSeq, Jul 2008].

HDAC1 Ontologies

Gene Ontology
Process: GO:10628; positive regulation of gene expression
GO:43066; negative regulation of apoptotic process
GO:45892; negative regulation of transcription, DNA-templated
GO:6325; chromatin organization
GO:6476; protein deacetylation
GO:16575; histone deacetylation
GO:122; negative regulation of transcription by RNA polymerase II
GO:48511; rhythmic process
GO:32922; circadian regulation of gene expression
GO:6357; regulation of transcription by RNA polymerase II
GO:6338; chromatin remodeling
And 35 more GO terms
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:32991; protein-containing complex
GO:5654; nucleoplasm
GO:5829; cytosol
GO:785; chromatin
GO:118; histone deacetylase complex
GO:16581; NuRD complex
GO:16580; Sin3 complex
GO:792; heterochromatin
GO:5667; transcription regulator complex
And 3 more GO terms
Function: GO:5515; protein binding
GO:46872; metal ion binding
GO:16787; hydrolase activity
GO:19899; enzyme binding
GO:978; RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:4407; histone deacetylase activity
GO:42826; histone deacetylase binding
GO:140297; DNA-binding transcription factor binding
GO:19213; deacetylase activity
GO:61629; RNA polymerase II-specific DNA-binding transcription factor binding
GO:3714; transcription corepressor activity
And 15 more GO terms
Show all GO terms

Homologs of HDAC1 in Model Organisms

Danio rerio
hdac1
Drosophila melanogaster
Rpd3
Mus musculus
Hdac1
Rattus norvegicus
Hdac1
Saccharomyces cerevisiae
RPD3

In other databases

GenAge model organism genes
  • A homolog of this gene for Saccharomyces cerevisiae is present as RPD3
  • A homolog of this gene for Drosophila melanogaster is present as Rpd3
GenAge human genes
  • This gene is present as HDAC1
GenDR gene manipulations
  • A homolog of this gene for Drosophila melanogaster is present as Rpd3
  • A homolog of this gene for Saccharomyces cerevisiae is present as RPD3

External links

OMIM
601241
Ensembl
ENSG00000116478
Entrez Gene
3065
UniGene
88556
1000 Genomes
1000 Genomes
HPRD
GenAtlas
HDAC1
GeneCards
HDAC1