Cell Senescence Entries for TFDP1

Cell Types
Cervical cancer, Lung cancer, Lung fibroblast
Cell Lines
A549, HeLa, WI-38
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Unclear
Senescence Effect
Inhibits
Primary Reference
Ohdaira et al. (2015) Acute loss of DP1, but not DP2, induces p53 mRNA and augments p21Waf1/Cip1 and senescence. Cell Biochem Funct 30(1)54-60 (PubMed)

TFDP1 Gene Information

HGNC symbol
TFDP1 
Aliases
DILC; Dp-1; DP1; DRTF1 
Common name
transcription factor Dp-1 
Entrez Id
7027
Description
This gene encodes a member of a family of transcription factors that heterodimerize with E2F proteins to enhance their DNA-binding activity and promote transcription from E2F target genes. The encoded protein functions as part of this complex to control the transcriptional activity of numerous genes involved in cell cycle progression from G1 to S phase. Alternative splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 1, 15, and X.[provided by RefSeq, Jan 2009].

TFDP1 Ontologies

Gene Ontology
Process: GO:7049; cell cycle
GO:6355; regulation of transcription, DNA-templated
GO:10468; regulation of gene expression
GO:51726; regulation of cell cycle
GO:8544; epidermis development
GO:43276; anoikis
GO:45893; positive regulation of transcription, DNA-templated
GO:45944; positive regulation of transcription by RNA polymerase II
GO:70345; negative regulation of fat cell proliferation
GO:2000278; regulation of DNA biosynthetic process
GO:6357; regulation of transcription by RNA polymerase II
And 6 more GO terms
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:5654; nucleoplasm
GO:5829; cytosol
GO:5667; transcription regulator complex
GO:785; chromatin
GO:90575; RNA polymerase II transcription regulator complex
GO:35189; Rb-E2F complex
Function: GO:3677; DNA binding
GO:3700; DNA-binding transcription factor activity
GO:5515; protein binding
GO:987; cis-regulatory region sequence-specific DNA binding
GO:977; RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:981; DNA-binding transcription factor activity, RNA polymerase II-specific
GO:140297; DNA-binding transcription factor binding
GO:19904; protein domain specific binding
GO:1228; DNA-binding transcription activator activity, RNA polymerase II-specific
Show all GO terms

Homologs of TFDP1 in Model Organisms

Danio rerio
tfdp1a
Mus musculus
Tfdp1

In other databases

GenAge human genes
  • This gene is present as TFDP1

External links

OMIM
189902
Ensembl
ENSG00000198176
Entrez Gene
7027
UniGene
79353
1000 Genomes
1000 Genomes
HPRD
GenAtlas
TFDP1
GeneCards
TFDP1