GenAge entry for TFDP1 (Homo sapiens)
Gene name (HAGRID: 202)
- HGNC symbol
- TFDP1
- Aliases
- Dp-1; DRTF1; DP1
- Common name
- transcription factor Dp-1
Potential relevance to the human ageing process
- Main reason for selection
- Entry selected based on evidence directly linking the gene product to ageing in a cellular model system
- Description
TFDP1 is a transcription factor that may play a role in cell cycle regulation and apoptosis [878]. Despite its association with cellular senescence [1569], TFDP1 has not been directly linked to organismal ageing.
Cytogenetic information
- Cytogenetic band
- 13q34
- Location
- 113,584,741 bp to 113,641,473 bp
- Orientation
- Plus strand
Protein information
- Gene Ontology
-
Process: GO:0006351; transcription, DNA-templated
GO:0006357; regulation of transcription from RNA polymerase II promoter
GO:0006977; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0008283; cell proliferation
GO:0045944; positive regulation of transcription from RNA polymerase II promoter
GO:0070345; negative regulation of fat cell proliferation
GO:1900740; positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
Cellular component: GO:0005634; nucleus
GO:0005654; nucleoplasm
GO:0005667; transcription factor complex
GO:0005739; mitochondrion
Show all GO termsFunction: GO:0000981; RNA polymerase II transcription factor activity, sequence-specific DNA binding
GO:0003677; DNA binding
GO:0003700; transcription factor activity, sequence-specific DNA binding
GO:0003713; transcription coactivator activity
GO:0005515; protein binding
GO:0008134; transcription factor binding
GO:0019904; protein domain specific binding
Protein interactions and network
- Protein-protein interacting partners in GenAge
- TP53, E2F1, CREBBP, RB1, CDK1, MAX, TP53BP1
- STRING interaction network
Retrieve sequences for TFDP1
Homologs in model organisms
In other databases
- CellAge
- This gene is present as TFDP1