Cell Senescence Entries for BCL2

Cell Types
Lung fibroblast
Cell Lines
IMR-90
Cancer Cell?
No
Method
Overexpression
Type of senescence
Oncogene-induced
Senescence Effect
Induces
Primary Reference
Tombor et al. (2003) Bcl-2 promotes premature senescence induced by oncogenic Ras. Biochem Biophys Res Commun 303(3)800-7 (PubMed)

BCL2 Gene Information

HGNC symbol
BCL2 
Aliases
Bcl-2; PPP1R50 
Common name
BCL2 apoptosis regulator 
Entrez Id
596
Description
This gene encodes an integral outer mitochondrial membrane protein that blocks the apoptotic death of some cells such as lymphocytes. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016].

BCL2 Ontologies

Gene Ontology
Process: GO:43066; negative regulation of apoptotic process
GO:6915; apoptotic process
GO:42981; regulation of apoptotic process
GO:12501; programmed cell death
GO:6974; cellular response to DNA damage stimulus
GO:51607; defense response to virus
GO:43065; positive regulation of apoptotic process
GO:80135; regulation of cellular response to stress
GO:55085; transmembrane transport
GO:9410; response to xenobiotic stimulus
GO:8630; intrinsic apoptotic signaling pathway in response to DNA damage
And 133 more GO terms
Cellular component: GO:16020; membrane
GO:16021; integral component of membrane
GO:5634; nucleus
GO:5737; cytoplasm
GO:5783; endoplasmic reticulum
GO:5789; endoplasmic reticulum membrane
GO:5654; nucleoplasm
GO:5739; mitochondrion
GO:5741; mitochondrial outer membrane
GO:31965; nuclear membrane
GO:32991; protein-containing complex
And 5 more GO terms
Function: GO:31625; ubiquitin protein ligase binding
GO:42802; identical protein binding
GO:5515; protein binding
GO:42803; protein homodimerization activity
GO:51434; BH3 domain binding
GO:2020; protease binding
GO:46982; protein heterodimerization activity
GO:43565; sequence-specific DNA binding
GO:140297; DNA-binding transcription factor binding
GO:15267; channel activity
GO:16248; channel inhibitor activity
And 3 more GO terms
Show all GO terms

Homologs of BCL2 in Model Organisms

Danio rerio
bcl2
Mus musculus
Bcl2
Rattus norvegicus
Bcl2

In other databases

GenAge human genes
  • This gene is present as BCL2

External links

OMIM
151430
Ensembl
ENSG00000171791
Entrez Gene
596
UniGene
150749
1000 Genomes
1000 Genomes
HPRD
GenAtlas
BCL2
GeneCards
BCL2