GenAge entry for CISD2 (Homo sapiens)

Entry selected based on evidence directly linking the gene product to ageing in a mammalian model organism

Gene name (HAGRID: 265)

HGNC symbol: CISD2
Aliases: Miner1; ERIS; NAF-1; ZCD2; WFS2
Common name: CDGSH iron sulfur domain 2

Potential relevance to the human ageing process

Main reason for selection: Entry selected based on evidence directly linking the gene product to ageing in a mammalian model organism
Description: Knockout mice for CISD2, the causative gene in Wolfram syndrome 2, show an increased mitochondrial breakdown and dysfunction accompanied by autophagic cell death. Mice exhibit multiple signs of premature aging: prominent eyes and protruding ears, ocular abnormalities, early depigmentation of the fur, hair follicle atrophy, decreased hair density and regrowth rate, thickened dermis, significant decrease in subcutaneous adipose tissue and muscle, muscle atrophy, osteroporosis, decrease in pulmonary capacity, and have a shorter lifespan [2153]. In wild type, the expression levels of CISD2 decrease with age [2154]. Transgenic expression in mice extend lifespan [3315]. As such, CISD2 is a strong candidate for a role in ageing, though further human studies are warranted.

Cytogenetic information

Cytogenetic band: 4q24
Location: 102,868,978 bp to 102,892,806 bp
Orientation: Plus strand

Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology

Process:

GO:0000422; mitophagy
GO:0010259; multicellular organism aging
GO:0010506; regulation of autophagy

Cellular component:

GO:0005741; mitochondrial outer membrane
GO:0005783; endoplasmic reticulum
GO:0005789; endoplasmic reticulum membrane
GO:0016020; membrane
GO:0016021; integral component of membrane
GO:0043234; protein complex

Function:

GO:0005515; protein binding
GO:0042803; protein homodimerization activity
GO:0044822; poly(A) RNA binding
GO:0046872; metal ion binding
GO:0051537; 2 iron, 2 sulfur cluster binding

Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge: LMNA, NRG1, BCL2, APP
STRING interaction network

Retrieve sequences for CISD2

ORF: ORF
CDS: CDS

Homologs in model organisms

Caenorhabditis elegans: CELE_W02B12.15
Danio rerio: cisd2
Drosophila melanogaster: CG1458
Mus musculus: Cisd2
Rattus norvegicus: Cisd2

In other databases

GenAge model organism genes

A homolog of this gene for Mus musculus is present as Cisd2