GenAge entry for APP (Homo sapiens)

Gene name (HAGRID: 137)

HGNC symbol: APP
Aliases: AD1
Common name: amyloid beta (A4) precursor protein

Potential relevance to the human ageing process

Main reason for selection: Entry selected based on indirect or inconclusive evidence linking the gene product to ageing in humans or in one or more model systems
Description: APP has different functions. It is a cell surface receptor, interacts with many other proteins, and may regulate neurite growth. Clearly, APP is an important player in Alzheimer's disease [695], though it is not known whether it is related to other aspects of ageing.

Cytogenetic information

Cytogenetic band: 21q21.3
Location: 25,880,550 bp to 26,170,820 bp
Orientation: Minus strand

Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology

Process:

GO:0001967; suckling behavior
GO:0002576; platelet degranulation
GO:0006378; mRNA polyadenylation
GO:0006417; regulation of translation
GO:0006468; protein phosphorylation
GO:0006878; cellular copper ion homeostasis
GO:0006897; endocytosis
GO:0006979; response to oxidative stress
GO:0007155; cell adhesion
GO:0007176; regulation of epidermal growth factor-activated receptor activity
GO:0007219; Notch signaling pathway

And 37 more GO terms

Cellular component:	GO:0005576; extracellular region GO:0005615; extracellular space GO:0005641; nuclear envelope lumen GO:0005737; cytoplasm GO:0005768; endosome GO:0005790; smooth endoplasmic reticulum GO:0005791; rough endoplasmic reticulum GO:0005794; Golgi apparatus GO:0005829; cytosol GO:0005886; plasma membrane GO:0005887; integral component of plasma membrane
	And 27 more GO terms

Function:	GO:0003677; DNA binding GO:0004867; serine-type endopeptidase inhibitor activity GO:0005102; receptor binding GO:0005515; protein binding GO:0008201; heparin binding GO:0016504; peptidase activator activity GO:0019899; enzyme binding GO:0042802; identical protein binding GO:0046914; transition metal ion binding GO:0051425; PTB domain binding GO:0070851; growth factor receptor binding
	And 1 more GO terms

Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge: SHC1, IGF1R, STAT5B, INS, IRS1, AKT1, MYC, EGFR, FOS, PRKCD, HSP90AA1, TOP1, UBE2I, TGFB1, STK11, GSK3B, CAT, FEN1, HSPA8, SOD2, LRP2, UCHL1, APP, A2M, ATP5O, ERCC1, HSPD1, MAPK8, YWHAZ, PTK2, IL7, JUN, HMGB2, MAP3K5, BDNF, ATF2, APEX1, PTGS2, HSPA9, MXD1, MDM2, UBB, MXI1, HOXB7, HOXC4, HELLS, CLU, CTNNB1, PSEN1, MAPT, PDPK1, CSNK1E, STUB1, CHEK2, PCK1, PPARG, CISD2, SIRT7, CDKN1A, CDKN2B, CDK7, CTF1, TRAP1
STRING interaction network

Retrieve sequences for APP

Promoter: Promoter
ORF: ORF
CDS: CDS

Homologs in model organisms

Danio rerio: appb
Mus musculus: App
Rattus norvegicus: App

In other databases

CellAge gene expression

This gene is present as APP