GenAge entry for GCLM (Homo sapiens)
Gene name (HAGRID: 238)
- HGNC symbol
- GCLM
- Aliases
- GLCLR
- Common name
- glutamate-cysteine ligase, modifier subunit
Potential relevance to the human ageing process
- Main reason for selection
- Entry selected based on evidence directly linking the gene product to ageing in a non-mammalian animal model
- Description
Glutamate-cysteine ligase, composed of GCLC and GCLM, catalyses the first step in glutathione synthesis. Overexpression of GCLM in fruit flies extended mean and maximum lifespan by up to 50% [1551]. In humans, polymorphisms in GCLM have been associated with myocardial infarction [1555].
Cytogenetic information
- Cytogenetic band
- 1p22.1
- Location
- 93,885,200 bp to 93,909,598 bp
- Orientation
- Minus strand
Protein information
- Gene Ontology
-
Process: GO:0000096; sulfur amino acid metabolic process
GO:0006534; cysteine metabolic process
GO:0006536; glutamate metabolic process
GO:0006750; glutathione biosynthetic process
GO:0006979; response to oxidative stress
GO:0007568; aging
GO:0007584; response to nutrient
GO:0008637; apoptotic mitochondrial changes
GO:0014823; response to activity
GO:0035229; positive regulation of glutamate-cysteine ligase activity
GO:0035729; cellular response to hepatocyte growth factor stimulus
And 13 more GO terms Cellular component: GO:0005829; cytosol
GO:0017109; glutamate-cysteine ligase complex
Show all GO termsFunction: GO:0004357; glutamate-cysteine ligase activity
GO:0030234; enzyme regulator activity
GO:0035226; glutamate-cysteine ligase catalytic subunit binding
GO:0046982; protein heterodimerization activity
Protein interactions and network
Retrieve sequences for GCLM
Homologs in model organisms
- Caenorhabditis elegans
- CELE_E01A2.1
- Danio rerio
- gclm
- Drosophila melanogaster
- Gclm
- Mus musculus
- Gclm
- Rattus norvegicus
- Gclm
- Schizosaccharomyces pombe
- SPCC737.06c
In other databases
- GenAge model organism genes
- A homolog of this gene for Drosophila melanogaster is present as Gclm