GenAge entry for GCLC (Homo sapiens)

Gene name (HAGRID: 237)

HGNC symbol: GCLC
Aliases: GCS; GLCLC; GLCL
Common name: glutamate-cysteine ligase, catalytic subunit

Potential relevance to the human ageing process

Main reason for selection: Entry selected based on evidence linking the gene product to a pathway or mechanism linked to ageing
Description: Glutamate-cysteine ligase, composed of GCLC and GCLM, catalyses the first step in glutathione synthesis. Overexpression of GCLC in fruit flies extended their mean lifespan by 24% [1551]. In humans, mutations in GCLC have been related to hemolytic anemia [1553] and susceptibility to myocardial infarction [1554].

Cytogenetic information

Cytogenetic band: 6p12
Location: 53,497,341 bp to 53,545,129 bp
Orientation: Minus strand

Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology

Process:

GO:0000096; sulfur amino acid metabolic process
GO:0006534; cysteine metabolic process
GO:0006536; glutamate metabolic process
GO:0006750; glutathione biosynthetic process
GO:0006979; response to oxidative stress
GO:0007568; aging
GO:0007584; response to nutrient
GO:0008637; apoptotic mitochondrial changes
GO:0009408; response to heat
GO:0009410; response to xenobiotic stimulus
GO:0009725; response to hormone

And 25 more GO terms

Cellular component:

GO:0005829; cytosol
GO:0017109; glutamate-cysteine ligase complex

Function:

GO:0000287; magnesium ion binding
GO:0004357; glutamate-cysteine ligase activity
GO:0005524; ATP binding
GO:0016595; glutamate binding
GO:0043531; ADP binding
GO:0046982; protein heterodimerization activity
GO:0050662; coenzyme binding

Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge: GCLM
STRING interaction network

Retrieve sequences for GCLC

ORF: ORF
CDS: CDS

Homologs in model organisms

Caenorhabditis elegans: gcs-1
Danio rerio: gclc
Drosophila melanogaster: Gclc
Mus musculus: Gclc
Rattus norvegicus: Gclc
Saccharomyces cerevisiae: GSH1
Schizosaccharomyces pombe: gcs1

In other databases

GenAge model organism genes

A homolog of this gene for Drosophila melanogaster is present as Gclc

GenDR gene manipulations

A homolog of this gene for Saccharomyces cerevisiae is present as GSH1

LongevityMap

This gene is present as GCLC