GenAge entry for PCMT1 (Homo sapiens)
Gene name (HAGRID: 162)
- HGNC symbol
- PCMT1
- Aliases
- Common name
- protein-L-isoaspartate (D-aspartate) O-methyltransferase
Potential relevance to the human ageing process
- Main reason for selection
- Entry selected based on evidence linking the gene product to a pathway or mechanism linked to ageing
- Description
PCMT1 is involved in the repair and degradation of damaged proteins. Overexpression of a PCMT1 homologue in fruit flies extends lifespan in a temperature-dependent fashion [211]. PCMT1-deficient mice die at about 42 days after birth, though without signs of premature ageing [760]. Although an age-related accumulation of defective proteins has been suggested as a factor in ageing, further research is needed to assess PCMT1's role, if any, in mammalian ageing.
Cytogenetic information
- Cytogenetic band
- 6q24-q25
- Location
- 149,749,695 bp to 149,811,421 bp
- Orientation
- Plus strand
Protein information
- Gene Ontology
-
Process: GO:0006479; protein methylation
GO:0030091; protein repair
GO:0098609; cell-cell adhesion
Cellular component: GO:0005737; cytoplasm
GO:0005829; cytosol
GO:0005913; cell-cell adherens junction
GO:0070062; extracellular exosome
GO:1903561; extracellular vesicle
Show all GO termsFunction: GO:0004719; protein-L-isoaspartate (D-aspartate) O-methyltransferase activity
GO:0005515; protein binding
GO:0098641; cadherin binding involved in cell-cell adhesion
Protein interactions and network
- Protein-protein interacting partners in GenAge
- TP53, LMNA, TERF1, TERF2, SOD1, APOE, CSNK1E, TP53BP1, MIF, TRAP1
- STRING interaction network
Retrieve sequences for PCMT1
Homologs in model organisms
- Caenorhabditis elegans
- pcm-1
- Danio rerio
- pcmt
- Drosophila melanogaster
- Pcmt
- Mus musculus
- Pcmt1
- Rattus norvegicus
- Pcmt1
- Schizosaccharomyces pombe
- pcm2
In other databases
- GenAge model organism genes