GenAge entry for SST (Homo sapiens)
Gene name (HAGRID: 53)
- HGNC symbol
- SST
- Aliases
- SMST
- Common name
- somatostatin
Potential relevance to the human ageing process
- Main reason for selection
- Entry selected based on evidence linking the gene product to the regulation or control of genes previously linked to ageing
- Description
Somatostatin is an important regulator of endocrine and nervous system function [386]. It inhibits the release of GH1 probably through GHRH [1568]. Because its levels change with age, it is likely that age-related changes are affected or affect SST [385], and a role for SST in Alzheimer's disease has also been proposed [1664].
Cytogenetic information
- Cytogenetic band
- 3q28
- Location
- 187,668,906 bp to 187,670,413 bp
- Orientation
- Minus strand
Protein information
- Gene Ontology
-
Process: GO:0006972; hyperosmotic response
GO:0007166; cell surface receptor signaling pathway
GO:0007186; G-protein coupled receptor signaling pathway
GO:0007267; cell-cell signaling
GO:0007268; chemical synaptic transmission
GO:0007584; response to nutrient
GO:0007586; digestion
GO:0008285; negative regulation of cell proliferation
GO:0008628; hormone-mediated apoptotic signaling pathway
GO:0009408; response to heat
GO:0010447; response to acidic pH
And 5 more GO terms Cellular component: GO:0005576; extracellular region
GO:0005615; extracellular space
GO:0043025; neuronal cell body
Show all GO termsFunction: GO:0005179; hormone activity
