GenAge entry for UBB (Homo sapiens)
Gene name (HAGRID: 66)
- HGNC symbol
- UBB
- Aliases
- MGC8385; FLJ25987
- Common name
- ubiquitin B
Potential relevance to the human ageing process
- Main reason for selection
- Entry selected based on indirect or inconclusive evidence linking the gene product to ageing in humans or in one or more model systems
- Description
UBB is involved in the regulation of chromatin structure and stress response, as well as in the degradation of cellular proteins [439]. In lower life forms, such as invertebrates, stress-response proteins similar to UBB have been associated with ageing. UBB has also been associated with neurodegenerative diseases [436]. Although unproven, a role for UBB in ageing and/or age-related diseases is possible.
Cytogenetic information
- Cytogenetic band
- 17p12-p11.
- Location
- 16,380,797 bp to 16,382,745 bp
- Orientation
- Plus strand
Protein information
- Gene Ontology
-
Process: GO:0000086; G2/M transition of mitotic cell cycle
GO:0000122; negative regulation of transcription from RNA polymerase II promoter
GO:0000165; MAPK cascade
GO:0000187; activation of MAPK activity
GO:0000209; protein polyubiquitination
GO:0000715; nucleotide-excision repair, DNA damage recognition
GO:0000717; nucleotide-excision repair, DNA duplex unwinding
GO:0002223; stimulatory C-type lectin receptor signaling pathway
GO:0002755; MyD88-dependent toll-like receptor signaling pathway
GO:0002756; MyD88-independent toll-like receptor signaling pathway
GO:0005978; glycogen biosynthetic process
And 66 more GO terms Cellular component: GO:0005615; extracellular space
GO:0005634; nucleus
GO:0005654; nucleoplasm
GO:0005739; mitochondrion
GO:0005829; cytosol
GO:0005886; plasma membrane
GO:0010008; endosome membrane
GO:0030666; endocytic vesicle membrane
GO:0043005; neuron projection
GO:0043025; neuronal cell body
GO:0070062; extracellular exosome
And 1 more GO terms
Show all GO termsFunction: GO:0005515; protein binding
Protein interactions and network
- Protein-protein interacting partners in GenAge
- TP53, VCP, APP, CDKN1A, SPRTN
- STRING interaction network
