GenAge entry for ARHGAP1 (Homo sapiens)
Entry selected based on evidence directly linking the gene product to ageing in a mammalian model organism
Gene name (HAGRID: 249)
- HGNC symbol
- ARHGAP1
- Aliases
- RhoGAP; p50rhoGAP; CDC42GAP; Cdc42GAP
- Common name
- Rho GTPase activating protein 1
Potential relevance to the human ageing process
- Main reason for selection
- Entry selected based on evidence directly linking the gene product to ageing in a mammalian model organism
- Description
ARHGAP1 a GTPase activator of several proteins. In effect, it acts as a negative regulator of CDC42. Gene targeting of ARHGAP1 in mice results in a short lifespan of about 12 months and the development of multiple premature ageing-like phenotypes, suggesting that this gene may play a role in mammalian ageing [1840].
Cytogenetic information
- Cytogenetic band
- 11p11.2
- Location
- 46,677,075 bp to 46,700,665 bp
- Orientation
- Minus strand
Protein information
- Gene Ontology
-
Process: GO:0007264; small GTPase mediated signal transduction
GO:0007266; Rho protein signal transduction
GO:0009967; positive regulation of signal transduction
GO:0043547; positive regulation of GTPase activity
GO:0051056; regulation of small GTPase mediated signal transduction
GO:0098609; cell-cell adhesion
Cellular component: GO:0005737; cytoplasm
GO:0005829; cytosol
GO:0005913; cell-cell adherens junction
GO:0048471; perinuclear region of cytoplasm
GO:0070062; extracellular exosome
Hide GO termsFunction: GO:0005070; SH3/SH2 adaptor activity
GO:0005096; GTPase activator activity
GO:0005515; protein binding
GO:0017124; SH3 domain binding
GO:0098641; cadherin binding involved in cell-cell adhesion
Protein interactions and network
- Protein-protein interacting partners in GenAge
- EGFR, PIK3R1, CHEK2, ARHGAP1, CDC42
- STRING interaction network
Retrieve sequences for ARHGAP1
Homologs in model organisms
In other databases
- GenAge model organism genes
- A homolog of this gene for Mus musculus is present as Arhgap1