GenAge entry for CDC42 (Homo sapiens)

Gene name (HAGRID: 250)

HGNC symbol: CDC42
Aliases: G25K; CDC42Hs
Common name: cell division cycle 42

Potential relevance to the human ageing process

Main reason for selection: Entry selected based on evidence directly linking the gene product to ageing in a cellular model system
Description: CDC42 is regulates numerous signalling pathways, including cell cycle progression. Its activity increases with age in various mouse tissues. In mice, gene targeting of ARHGAP1, a negative regulator of CDC42, results in elevated levels of CDC42. The animals display multiple premature ageing-like phenotypes, suggesting this gene may play a role in mammalian ageing. CDC42 activation promotes a premature cellular senescence phenotype dependent on TP53 [1840].

Cytogenetic information

Cytogenetic band: 1p36.1
Location: 22,052,627 bp to 22,092,943 bp
Orientation: Plus strand

Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology

Process:

GO:0002040; sprouting angiogenesis
GO:0003161; cardiac conduction system development
GO:0003334; keratinocyte development
GO:0007030; Golgi organization
GO:0007088; regulation of mitotic nuclear division
GO:0007097; nuclear migration
GO:0007163; establishment or maintenance of cell polarity
GO:0007264; small GTPase mediated signal transduction
GO:0007596; blood coagulation
GO:0010628; positive regulation of gene expression
GO:0010629; negative regulation of gene expression

And 53 more GO terms

Cellular component:	GO:0000139; Golgi membrane GO:0000322; storage vacuole GO:0005737; cytoplasm GO:0005789; endoplasmic reticulum membrane GO:0005815; microtubule organizing center GO:0005829; cytosol GO:0005886; plasma membrane GO:0005911; cell-cell junction GO:0005925; focal adhesion GO:0016020; membrane GO:0030141; secretory granule
	And 12 more GO terms

Function:

GO:0003924; GTPase activity
GO:0005515; protein binding
GO:0005525; GTP binding
GO:0019901; protein kinase binding
GO:0030742; GTP-dependent protein binding
GO:0031435; mitogen-activated protein kinase kinase kinase binding
GO:0031996; thioesterase binding
GO:0034191; apolipoprotein A-I receptor binding
GO:0042802; identical protein binding
GO:0051022; Rho GDP-dissociation inhibitor binding
GO:0061630; ubiquitin protein ligase activity

And 1 more GO terms

Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge: TP53, RAD51, TNF, ERCC3, GRB2, A2M, PRDX1, MT-CO1, MAPK8, MAPK9, DBN1, ARHGAP1, CDC42
STRING interaction network

Retrieve sequences for CDC42

ORF: ORF
CDS: CDS

Homologs in model organisms

Caenorhabditis elegans: cdc-42
Danio rerio: cdc42
Drosophila melanogaster: Cdc42
Mus musculus: Cdc42
Rattus norvegicus: Cdc42
Saccharomyces cerevisiae: CDC42
Schizosaccharomyces pombe: cdc42