GenAge entry for CDKN2B (Homo sapiens)

Gene name (HAGRID: 288)

HGNC symbol: CDKN2B
Aliases: P15; MTS2; INK4B; TP15; CDK4I; p15INK4b
Common name: cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)

Potential relevance to the human ageing process

Main reason for selection: Entry selected based on evidence directly linking the gene product to ageing in a cellular model system
Description: The p15 tumor suppressor (CDKN2B) is located in the same region as p16 (CDKN2A), and is also involved in cell cycle, senescence and cancer. This region is frequently mutated and/or deleted in a wide variety of tumors [2229]. Genetic variants have been identified close to both p15 and p16 in patients with type 2 diabetes and cardiovascular disease [2230]. Although CDKN2B seems to have a role in cellular senescence and age-related diseases, its implication in broader aspects of ageing is still unknown.

Cytogenetic information

Cytogenetic band: 9p21
Location: 22,002,903 bp to 22,009,313 bp
Orientation: Minus strand

Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology

Process:

GO:0000079; regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0000086; G2/M transition of mitotic cell cycle
GO:0007050; cell cycle arrest
GO:0007093; mitotic cell cycle checkpoint
GO:0008285; negative regulation of cell proliferation
GO:0030219; megakaryocyte differentiation
GO:0030511; positive regulation of transforming growth factor beta receptor signaling pathway
GO:0031668; cellular response to extracellular stimulus
GO:0031670; cellular response to nutrient
GO:0042326; negative regulation of phosphorylation
GO:0045944; positive regulation of transcription from RNA polymerase II promoter
GO:0048536; spleen development
GO:0050680; negative regulation of epithelial cell proliferation
GO:0071901; negative regulation of protein serine/threonine kinase activity
GO:2000134; negative regulation of G1/S transition of mitotic cell cycle

Cellular component:

GO:0005634; nucleus
GO:0005654; nucleoplasm
GO:0005737; cytoplasm
GO:0005829; cytosol

Function:

GO:0004861; cyclin-dependent protein serine/threonine kinase inhibitor activity
GO:0005515; protein binding
GO:0019901; protein kinase binding

Hide GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge: APP
STRING interaction network

Retrieve sequences for CDKN2B

ORF: ORF
CDS: CDS

Homologs in model organisms

Danio rerio: LOC100329528
Mus musculus: Cdkn2b
Rattus norvegicus: Cdkn2b

In other databases

LongevityMap

This gene is present as CDKN2B

CellAge

This gene is present as CDKN2B

CellAge gene expression

This gene is present as CDKN2B