GenAge entry for CETP (Homo sapiens)

Gene name (HAGRID: 262)

HGNC symbol: CETP
Aliases: BPIFF
Common name: cholesteryl ester transfer protein, plasma

Potential relevance to the human ageing process

Main reason for selection

Entry selected based on evidence linking the gene or its product to human longevity and/or multiple age-related phenotypes

Description

The cholesteryl ester transfer protein (CETP) is a protein involved in the transfer of cholesteryl esters between lipoproteins. CETP is a crucial protein involved in the regulation of high density lipoprotein (HDL) levels and may affect susceptibility to age-related diseases, including atherosclerosis and Alzheimer's Disease (AD). A higher HDL/LDL ratio has been associated with healthier and longer-lived individuals. Accordingly, a polymorphism (I405V) in the CETP gene has been associated with longevity in some long-lived populations of healthy aging Ashkenazi Jews [2127] as well as in a cohort of Greek individuals [2128]. This however was not observed in a similar study with Italian centenaries [2129] and it appears that this polymorphism is not enough to universally determine longevity and other genes might play an important role.

CETP has been also associated with susceptibility to age-related diseases. For example, it was suggested that CETP behaves as a modifier gene of the AD risk associated with APOE [2130] and that the I405V polymorphism is associated with an increased risk of AD [2131]. CETP has been also identified as a susceptibility allele for advanced age-related macular degeneration [2133].

Cytogenetic information

Cytogenetic band: 16q21
Location: 56,961,923 bp to 56,983,844 bp
Orientation: Plus strand

Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology

Process:

GO:0006641; triglyceride metabolic process
GO:0006869; lipid transport
GO:0006898; receptor-mediated endocytosis
GO:0008203; cholesterol metabolic process
GO:0010745; negative regulation of macrophage derived foam cell differentiation
GO:0010874; regulation of cholesterol efflux
GO:0015914; phospholipid transport
GO:0030301; cholesterol transport
GO:0034197; triglyceride transport
GO:0034372; very-low-density lipoprotein particle remodeling
GO:0034374; low-density lipoprotein particle remodeling
GO:0034375; high-density lipoprotein particle remodeling
GO:0042157; lipoprotein metabolic process
GO:0042632; cholesterol homeostasis
GO:0043691; reverse cholesterol transport
GO:0046470; phosphatidylcholine metabolic process
GO:0055088; lipid homeostasis
GO:0055091; phospholipid homeostasis
GO:0070328; triglyceride homeostasis

Cellular component:

GO:0005576; extracellular region
GO:0005615; extracellular space
GO:0031982; vesicle
GO:0034364; high-density lipoprotein particle
GO:0070062; extracellular exosome

Function:

GO:0005319; lipid transporter activity
GO:0005548; phospholipid transporter activity
GO:0008289; lipid binding
GO:0015485; cholesterol binding
GO:0017127; cholesterol transporter activity
GO:0017129; triglyceride binding
GO:0031210; phosphatidylcholine binding

Hide GO terms

Protein interactions and network

No interactions in records.

Retrieve sequences for CETP

ORF: ORF
CDS: CDS

Homologs in model organisms

Danio rerio: cetp

In other databases

LongevityMap

This gene is present as CETP