GenAge entry for COQ7 (Homo sapiens)

Gene name (HAGRID: 132)

Main reason for selection: Entry selected based on evidence directly linking the gene product to ageing in a non-mammalian animal model
Description: COQ7's functions are unclear, but it may be a metabolic regulator involved in several metabolic pathways such as the biosynthesis of ubiquinone, in turn an antioxidant involved in mitochondrial respiration [675]. In roundworms, the COQ7 homologue clk-1 affects developmental timing and lifespan [946]. Food restriction does not further increase the lifespan of long-lived clk-1 mutants, suggesting that clk-1 and caloric restriction affect similar processes [1820]. Knocking out COQ7 in mice results in developmental arrest at midgestation [1613]. Heterozygous mice live about 15 to 30% longer than controls, though it is unclear whether ageing is delayed [1612]. They also exhibit surprisingly high levels of oxidative damage and early mitochondrial dysfunction [2087]. Although it is possible for COQ7 to play a role in human ageing, further research is needed to investigate this possibility.

Display region using the UCSC Genome Browser (GRCh38/hg38)

Gene Ontology

Process:

GO:0006744; ubiquinone biosynthetic process
GO:0055114; oxidation-reduction process

Cellular component:

GO:0005634; nucleus
GO:0005743; mitochondrial inner membrane

Function:

GO:0004497; monooxygenase activity
GO:0005515; protein binding
GO:0046872; metal ion binding

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