GenAge entry for CTGF (Homo sapiens)

Gene name (HAGRID: 206)

HGNC symbol: CTGF
Aliases: IGFBP8; CCN2
Common name: connective tissue growth factor

Potential relevance to the human ageing process

Main reason for selection: Entry selected based on indirect or inconclusive evidence linking the gene product to ageing in humans or in one or more model systems
Description: CTGF is an important growth factor secreted by vascular endothelial cells. Overexpression of CTGF in mice resulted in dwarfism and decreased bone density [884]. Age-related upregulation of CTGF in senescent cells and in rat liver has also been reported [1737]. Further studies are necessary to determined whether CTGF influences human ageing.

Cytogenetic information

Cytogenetic band: 6q23.1
Location: 131,948,177 bp to 131,951,378 bp
Orientation: Minus strand

Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology

Process:

GO:0001502; cartilage condensation
GO:0001503; ossification
GO:0001525; angiogenesis
GO:0001558; regulation of cell growth
GO:0001894; tissue homeostasis
GO:0006367; transcription initiation from RNA polymerase II promoter
GO:0007155; cell adhesion
GO:0007160; cell-matrix adhesion
GO:0007229; integrin-mediated signaling pathway
GO:0007267; cell-cell signaling
GO:0007568; aging
GO:0008284; positive regulation of cell proliferation
GO:0008543; fibroblast growth factor receptor signaling pathway
GO:0008544; epidermis development
GO:0009611; response to wounding
GO:0009749; response to glucose
GO:0010628; positive regulation of gene expression
GO:0010629; negative regulation of gene expression
GO:0016477; cell migration
GO:0030154; cell differentiation
GO:0030324; lung development
GO:0032330; regulation of chondrocyte differentiation
GO:0032355; response to estradiol
GO:0032967; positive regulation of collagen biosynthetic process
GO:0034059; response to anoxia
GO:0035556; intracellular signal transduction
GO:0035988; chondrocyte proliferation
GO:0043200; response to amino acid
GO:0043280; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043434; response to peptide hormone
GO:0045597; positive regulation of cell differentiation
GO:0046330; positive regulation of JNK cascade
GO:0050867; positive regulation of cell activation
GO:0051385; response to mineralocorticoid
GO:0051496; positive regulation of stress fiber assembly
GO:0060401; cytosolic calcium ion transport
GO:0060452; positive regulation of cardiac muscle contraction
GO:0060548; negative regulation of cell death
GO:0070278; extracellular matrix constituent secretion
GO:0070318; positive regulation of G0 to G1 transition
GO:0070374; positive regulation of ERK1 and ERK2 cascade
GO:0070542; response to fatty acid
GO:0071897; DNA biosynthetic process
GO:0072593; reactive oxygen species metabolic process

Cellular component:

GO:0005576; extracellular region
GO:0005578; proteinaceous extracellular matrix
GO:0005615; extracellular space
GO:0005794; Golgi apparatus
GO:0005801; cis-Golgi network
GO:0005829; cytosol
GO:0005886; plasma membrane
GO:0005938; cell cortex
GO:0043231; intracellular membrane-bounded organelle
GO:0048471; perinuclear region of cytoplasm

Function:

GO:0001968; fibronectin binding
GO:0005178; integrin binding
GO:0005515; protein binding
GO:0005520; insulin-like growth factor binding
GO:0008022; protein C-terminus binding
GO:0008083; growth factor activity
GO:0008201; heparin binding

Hide GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge: EGFR, VEGFA
STRING interaction network

Retrieve sequences for CTGF

Promoter: Promoter
ORF: ORF
CDS: CDS

Homologs in model organisms

Danio rerio: ctgfa
Mus musculus: Ctgf
Rattus norvegicus: Ctgf

In other databases

GenDR gene expression

A homolog of this gene for Mus musculus is present as Ctgf

CellAge

This gene is present as CCN2

CellAge gene expression

This gene is present as CTGF