GenAge entry for HIC1 (Homo sapiens)
Gene name (HAGRID: 253)
- HGNC symbol
- HIC1
- Aliases
- ZBTB29; ZNF901
- Common name
- hypermethylated in cancer 1
Potential relevance to the human ageing process
- Main reason for selection
- Entry selected based on evidence linking the gene product to the regulation or control of genes previously linked to ageing
- Description
HIC1 is a transcriptional repressor. It suppresses age-dependent development of cancer in mice together with TP53. HIC1 also forms a complex with SIRT1 that represses SIRT1 expression. Ageing increases promoter hypermethylation and epigenetic silencing of HIC1 [1582]. Therefore, HIC1 might play some role in ageing, though further studies are warranted.
Cytogenetic information
- Cytogenetic band
- 17p13.3
- Location
- 2,055,099 bp to 2,059,687 bp
- Orientation
- Plus strand
Protein information
- Gene Ontology
-
Process: GO:0000122; negative regulation of transcription from RNA polymerase II promoter
GO:0006351; transcription, DNA-templated
GO:0006355; regulation of transcription, DNA-templated
GO:0007275; multicellular organism development
GO:0008630; intrinsic apoptotic signaling pathway in response to DNA damage
GO:0016055; Wnt signaling pathway
GO:0030178; negative regulation of Wnt signaling pathway
GO:0043517; positive regulation of DNA damage response, signal transduction by p53 class mediator
Cellular component: GO:0000785; chromatin
GO:0005654; nucleoplasm
GO:0005737; cytoplasm
Hide GO termsFunction: GO:0003700; transcription factor activity, sequence-specific DNA binding
GO:0005515; protein binding
GO:0042826; histone deacetylase binding
GO:0043565; sequence-specific DNA binding
GO:0046872; metal ion binding
Protein interactions and network
- Protein-protein interacting partners in GenAge
- STAT3, UBE2I, SIRT1, SP1, HIC1
- STRING interaction network
Retrieve sequences for HIC1
Homologs in model organisms
- Danio rerio
- hic1
- Mus musculus
- Hic1
- Rattus norvegicus
- LOC100912068