GenAge entry for HMGB2 (Homo sapiens)

Gene name (HAGRID: 178)

HGNC symbol: HMGB2
Aliases: HMG2
Common name: high mobility group box 2

Potential relevance to the human ageing process

Main reason for selection: Entry selected based on evidence showing that the gene product to be a target of genes previously linked to ageing
Description: HMGB2 has been related to DNA unwinding and stress response. In mice, HMGB2 and other HMG chromosomal proteins have been shown to suffer alterations at various levels during ageing [790], though HMGB2 has not been directly related to human ageing.

Cytogenetic information

Cytogenetic band: 4q31
Location: 173,331,376 bp to 173,334,444 bp
Orientation: Minus strand

Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology

Process:

GO:0001938; positive regulation of endothelial cell proliferation
GO:0002437; inflammatory response to antigenic stimulus
GO:0006265; DNA topological change
GO:0006309; apoptotic DNA fragmentation
GO:0006325; chromatin organization
GO:0006334; nucleosome assembly
GO:0006351; transcription, DNA-templated
GO:0006357; regulation of transcription from RNA polymerase II promoter
GO:0007289; spermatid nucleus differentiation
GO:0008584; male gonad development
GO:0032075; positive regulation of nuclease activity
GO:0032392; DNA geometric change
GO:0032496; response to lipopolysaccharide
GO:0032728; positive regulation of interferon-beta production
GO:0033151; V(D)J recombination
GO:0042493; response to drug
GO:0043388; positive regulation of DNA binding
GO:0045087; innate immune response
GO:0045089; positive regulation of innate immune response
GO:0045648; positive regulation of erythrocyte differentiation
GO:0045654; positive regulation of megakaryocyte differentiation
GO:0045892; negative regulation of transcription, DNA-templated
GO:0045893; positive regulation of transcription, DNA-templated
GO:0045944; positive regulation of transcription from RNA polymerase II promoter
GO:0048545; response to steroid hormone
GO:0050767; regulation of neurogenesis
GO:0050829; defense response to Gram-negative bacterium
GO:0050830; defense response to Gram-positive bacterium
GO:0050918; positive chemotaxis
GO:0051103; DNA ligation involved in DNA repair
GO:0060326; cell chemotaxis
GO:0071222; cellular response to lipopolysaccharide
GO:0072091; regulation of stem cell proliferation
GO:1902042; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors

Cellular component:

GO:0000790; nuclear chromatin
GO:0000793; condensed chromosome
GO:0005615; extracellular space
GO:0005623; cell
GO:0005634; nucleus
GO:0005654; nucleoplasm
GO:0005730; nucleolus
GO:0005737; cytoplasm
GO:0043234; protein complex
GO:0048471; perinuclear region of cytoplasm

Function:

GO:0000400; four-way junction DNA binding
GO:0001158; enhancer sequence-specific DNA binding
GO:0003677; DNA binding
GO:0003684; damaged DNA binding
GO:0003690; double-stranded DNA binding
GO:0003697; single-stranded DNA binding
GO:0003700; transcription factor activity, sequence-specific DNA binding
GO:0005515; protein binding
GO:0008134; transcription factor binding
GO:0008144; drug binding
GO:0008301; DNA binding, bending
GO:0019904; protein domain specific binding
GO:0042056; chemoattractant activity
GO:0044212; transcription regulatory region DNA binding
GO:0044378; non-sequence-specific DNA binding, bending
GO:0044822; poly(A) RNA binding
GO:0050786; RAGE receptor binding
GO:0097100; supercoiled DNA binding

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Protein interactions and network

Protein-protein interacting partners in GenAge: CREBBP, NR3C1, AR, APP, HMGB1
STRING interaction network

Retrieve sequences for HMGB2

Promoter: Promoter
ORF: ORF
CDS: CDS

Homologs in model organisms

Danio rerio: hmgb2a
Mus musculus: Hmgb2
Rattus norvegicus: Hmgb2

In other databases

CellAge

This gene is present as HMGB2

CellAge gene expression

This gene is present as HMGB2