GenAge entry for HSPA1B (Homo sapiens)

Gene name (HAGRID: 161)

HGNC symbol: HSPA1B
Aliases: HSP70-2
Common name: heat shock 70kDa protein 1B

Potential relevance to the human ageing process

Main reason for selection: Entry selected based on evidence linking the gene product to a pathway or mechanism linked to ageing
Description: HSPA1B is involved in stress response and recognition of abnormal proteins, but also in signalling cascades. Results from invertebrates have suggested that heat-shock proteins, such as hsp70, a homologue of HSPA1B, are involved in ageing [210]. Whether HSPA1B is involved in human ageing is unknown.

Cytogenetic information

Cytogenetic band: 6p21.3
Location: 3,075,514 bp to 3,078,033 bp
Orientation: Plus strand

Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology

Process:

GO:0010628; positive regulation of gene expression
GO:0010941; regulation of cell death
GO:0031396; regulation of protein ubiquitination
GO:0031397; negative regulation of protein ubiquitination
GO:0032757; positive regulation of interleukin-8 production
GO:0034599; cellular response to oxidative stress
GO:0034605; cellular response to heat
GO:0042026; protein refolding
GO:0046034; ATP metabolic process
GO:0046718; viral entry into host cell
GO:0050821; protein stabilization
GO:0051092; positive regulation of NF-kappaB transcription factor activity
GO:0060548; negative regulation of cell death
GO:0070370; cellular heat acclimation
GO:0070434; positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway
GO:0090084; negative regulation of inclusion body assembly
GO:1900034; regulation of cellular response to heat
GO:1903265; positive regulation of tumor necrosis factor-mediated signaling pathway
GO:2001240; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand

Cellular component:

GO:0000151; ubiquitin ligase complex
GO:0005654; nucleoplasm
GO:0005737; cytoplasm
GO:0005814; centriole
GO:0005829; cytosol
GO:0005925; focal adhesion
GO:0016234; inclusion body
GO:0048471; perinuclear region of cytoplasm
GO:0072562; blood microparticle

Function:

GO:0001618; virus receptor activity
GO:0001664; G-protein coupled receptor binding
GO:0005102; receptor binding
GO:0005515; protein binding
GO:0005524; ATP binding
GO:0016887; ATPase activity
GO:0019899; enzyme binding
GO:0031072; heat shock protein binding
GO:0031625; ubiquitin protein ligase binding
GO:0042623; ATPase activity, coupled
GO:0042826; histone deacetylase binding
GO:0044183; protein binding involved in protein folding
GO:0051082; unfolded protein binding
GO:0055131; C3HC4-type RING finger domain binding

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Protein interactions and network

Protein-protein interacting partners in GenAge: SHC1, TP53, EGFR, HSP90AA1, GRB2, YWHAZ, CTNNB1, STUB1
STRING interaction network

Retrieve sequences for HSPA1B

ORF: ORF
CDS: CDS

Homologs in model organisms

Caenorhabditis elegans: hsp-1
Danio rerio: hsp70l
Mus musculus: Hspa1b
Rattus norvegicus: Hspa1a

In other databases

LongevityMap

This gene is present as HSPA1B