GenAge entry for GRB2 (Homo sapiens)

Gene name (HAGRID: 122)

HGNC symbol: GRB2
Aliases: NCKAP2
Common name: growth factor receptor-bound protein 2

Potential relevance to the human ageing process

Main reason for selection: Entry selected based on evidence showing that the gene product to be a target of genes previously linked to ageing
Description: An important player in growth signalling pathways, GRB2's functions are not yet well understood. Analyses of mice with a null mutation in GRB2 suggest that GRB2 is required for embryonic development and malignant transformation [620]. Due to its role as a signal transducer of many pathways, including pathways and genes previously related to ageing such as INS/IGF1 signalling and SHC1 [1107], it is possible GRB2 plays some role in ageing.

Cytogenetic information

Cytogenetic band: 17q24-q25
Location: 75,318,076 bp to 75,405,708 bp
Orientation: Minus strand

Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology

Process:

GO:0000165; MAPK cascade
GO:0007173; epidermal growth factor receptor signaling pathway
GO:0007265; Ras protein signal transduction
GO:0007267; cell-cell signaling
GO:0007411; axon guidance
GO:0007568; aging
GO:0008286; insulin receptor signaling pathway
GO:0008543; fibroblast growth factor receptor signaling pathway
GO:0009967; positive regulation of signal transduction
GO:0014066; regulation of phosphatidylinositol 3-kinase signaling
GO:0016032; viral process

And 20 more GO terms

Cellular component:	GO:0005634; nucleus GO:0005654; nucleoplasm GO:0005730; nucleolus GO:0005737; cytoplasm GO:0005768; endosome GO:0005794; Golgi apparatus GO:0005829; cytosol GO:0005886; plasma membrane GO:0005911; cell-cell junction GO:0008180; COP9 signalosome GO:0012506; vesicle membrane
	And 3 more GO terms

Function:

GO:0001784; phosphotyrosine binding
GO:0005070; SH3/SH2 adaptor activity
GO:0005088; Ras guanyl-nucleotide exchange factor activity
GO:0005154; epidermal growth factor receptor binding
GO:0005168; neurotrophin TRKA receptor binding
GO:0005515; protein binding
GO:0016303; 1-phosphatidylinositol-3-kinase activity
GO:0017124; SH3 domain binding
GO:0019901; protein kinase binding
GO:0019903; protein phosphatase binding
GO:0042802; identical protein binding

And 5 more GO terms

Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge: GHR, SHC1, PTPN11, IRS1, PTPN1, IRS2, PIK3CB, EGFR, ERBB2, INSR, PDGFRB, EPOR, PPARA, RET, VCP, HSP90AA1, ABL1, EP300, HTT, RB1, GRB2, A2M, HSPA9, HSPD1, HSPA1B, YWHAZ, PTK2B, PTK2, MAPK9, PIK3R1, HSPA8, JAK2, CLU, PPP1CA, DBN1, CDC42, EPS8, PDGFRA, PIK3CA
STRING interaction network

Retrieve sequences for GRB2

ORF: ORF
CDS: CDS

Homologs in model organisms

Danio rerio: grb2b
Drosophila melanogaster: drk
Mus musculus: Grb2
Rattus norvegicus: Grb2

In other databases

LongevityMap

This gene is present as GRB2