GenAge entry for IGFBP3 (Homo sapiens)

Gene name (HAGRID: 73)

HGNC symbol: IGFBP3
Aliases: IBP3; BP-53
Common name: insulin-like growth factor binding protein 3

Potential relevance to the human ageing process

Main reason for selection: Entry selected based on evidence linking the gene product to the regulation or control of genes previously linked to ageing
Description: IGFBP3 is a member of the IGFBP family that regulates IGF1 and IGF2 by altering the interaction of IGFs with their cell surface receptors. Some evidence suggests that IGFBP3 influences age-related changes in lean body mass [457], but so far it has not been directly linked to human ageing.

Cytogenetic information

Cytogenetic band: 7p13-p12
Location: 45,912,245 bp to 45,921,272 bp
Orientation: Minus strand

Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology

Process:

GO:0001558; regulation of cell growth
GO:0001649; osteoblast differentiation
GO:0001933; negative regulation of protein phosphorylation
GO:0006468; protein phosphorylation
GO:0006915; apoptotic process
GO:0008285; negative regulation of cell proliferation
GO:0009968; negative regulation of signal transduction
GO:0010906; regulation of glucose metabolic process
GO:0014912; negative regulation of smooth muscle cell migration
GO:0042981; regulation of apoptotic process
GO:0043065; positive regulation of apoptotic process
GO:0043085; positive regulation of catalytic activity
GO:0043410; positive regulation of MAPK cascade
GO:0043567; regulation of insulin-like growth factor receptor signaling pathway
GO:0043568; positive regulation of insulin-like growth factor receptor signaling pathway
GO:0044267; cellular protein metabolic process
GO:0044342; type B pancreatic cell proliferation
GO:0045663; positive regulation of myoblast differentiation
GO:0048662; negative regulation of smooth muscle cell proliferation

Cellular component:

GO:0005576; extracellular region
GO:0005615; extracellular space
GO:0005634; nucleus
GO:0016942; insulin-like growth factor binding protein complex
GO:0042567; insulin-like growth factor ternary complex
GO:0070062; extracellular exosome

Function:

GO:0001968; fibronectin binding
GO:0005515; protein binding
GO:0005520; insulin-like growth factor binding
GO:0008160; protein tyrosine phosphatase activator activity
GO:0031994; insulin-like growth factor I binding
GO:0031995; insulin-like growth factor II binding
GO:0046872; metal ion binding

Hide GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge: IGF1R, IGF1, IGF2, PPARG
STRING interaction network

Retrieve sequences for IGFBP3

Promoter: Promoter
ORF: ORF
CDS: CDS

Homologs in model organisms

Danio rerio: igfbp3
Mus musculus: Igfbp3
Rattus norvegicus: Igfbp3

In other databases

LongevityMap

This gene is present as IGFBP3

CellAge

This gene is present as IGFBP3

CellAge gene expression

This gene is present as IGFBP3