GenAge entry for IGF1R (Homo sapiens)

Gene name (HAGRID: 15)

HGNC symbol: IGF1R
Aliases: JTK13; CD221; IGFIR; MGC18216; IGFR
Common name: insulin-like growth factor 1 receptor

Potential relevance to the human ageing process

Main reason for selection

Entry selected based on evidence directly linking the gene product to ageing in a non-mammalian animal model

Description

The receptor for IGF1, IGF1R, mediates the activation of the IGF1-stimulated signalling cascade. Evidence from model organisms, including results from flies [187] and roundworms [239], relates IGF1R homologues to ageing, most likely as part of the GH1/IGF1 axis. Mice (129/SvPas genetic background) heterozygous for IGF1R live 26% longer, though it is unclear whether they age slower. Null mutants are not viable [18]. In the B6 genetic background however, IGF-1R+/- female mutants show only an 11% lifespan extension, while males do not show any changes in median lifespan and have a slightly shorter maximum lifespan [3549]. In male mice where IGF1R has been knocked out specifically in cardiomyocytes, cardiac ageing is attenuated. Fibrosis and expression of proinflammatory cytokines and NFKB1 are reduced when compared to wild type mice [4351]. IGF1R integrates nutrient and temperature homeostasis in mice and a reduction in IGF1R enhances the reduction of temperature and energy expenditure seen during calorie restriction. Therefore, IGF1 signalling plays a role in regulating hypothermia during calorie restriction [4502].

The IGF1/GH1 axis appears to impact on ageing in model organisms, including rodents, and so IGF1R may affect human ageing. In humans, IGF1R has been implicated with growth retardation [186], and genotype combinations in the human IGF1R and PIK3CB genes have been related to plasma IGF1 levels and longevity [141].

Cytogenetic information

Cytogenetic band: 15q26.3
Location: 98,648,539 bp to 98,964,530 bp
Orientation: Plus strand

Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology

Process:

GO:0006955; immune response
GO:0007165; signal transduction
GO:0008284; positive regulation of cell proliferation
GO:0008286; insulin receptor signaling pathway
GO:0014065; phosphatidylinositol 3-kinase signaling
GO:0030335; positive regulation of cell migration
GO:0038083; peptidyl-tyrosine autophosphorylation
GO:0043066; negative regulation of apoptotic process
GO:0045740; positive regulation of DNA replication
GO:0046328; regulation of JNK cascade
GO:0046777; protein autophosphorylation

And 5 more GO terms

Cellular component:

GO:0005886; plasma membrane
GO:0005887; integral component of plasma membrane
GO:0016020; membrane
GO:0035867; alphav-beta3 integrin-IGF-1-IGF1R complex
GO:0043231; intracellular membrane-bounded organelle
GO:0043235; receptor complex

Function:

GO:0004713; protein tyrosine kinase activity
GO:0005010; insulin-like growth factor-activated receptor activity
GO:0005158; insulin receptor binding
GO:0005515; protein binding
GO:0005520; insulin-like growth factor binding
GO:0005524; ATP binding
GO:0031994; insulin-like growth factor I binding
GO:0042802; identical protein binding
GO:0043548; phosphatidylinositol 3-kinase binding
GO:0043559; insulin binding
GO:0043560; insulin receptor substrate binding

And 1 more GO terms

Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge: SHC1, TP53, PTPN11, STAT3, IGF1, IRS1, PTPN1, EGFR, ERBB2, IGFBP3, HSP90AA1, APP, PTK2, PIK3R1, MDM2, ESR1, SOCS2
STRING interaction network

Retrieve sequences for IGF1R

ORF: ORF
CDS: CDS

Homologs in model organisms

Danio rerio: igf1rb
Mus musculus: Igf1r
Rattus norvegicus: Igf1r

In other databases

GenAge model organism genes

A homolog of this gene for Mus musculus is present as Igf1r

LongevityMap

This gene is present as IGF1R