GenAge entry for IL6 (Homo sapiens)

Gene name (HAGRID: 144)

HGNC symbol: IL6
Aliases: IL-6; BSF2; HGF; HSF; IFNB2
Common name: interleukin 6

Potential relevance to the human ageing process

Main reason for selection: Entry selected based on indirect or inconclusive evidence linking the gene product to ageing in humans or in one or more model systems
Description: IL6 is involved in a variety of processes such as development, differentiation, and inflammation [720]. Mice without IL6 have a defective hepatocyte regeneration and develop liver failure [721]. Transgenic mice expressing high levels of IL6 have a reduced growth rate and low levels of IGF1 [722]. Its levels appear to increase with age, possibly associating IL6 with age-related changes, such as chronic inflammatory diseases [717]. Polymorphisms in the human IL6 gene have been linked to age-related diseases, such as cardiovascular diseases [1050], though they have not been associated with longevity [221]. A role for IL6 in human ageing is plausible though largely obscure.

Cytogenetic information

Cytogenetic band: 7p21
Location: 22,727,147 bp to 22,732,002 bp
Orientation: Plus strand

Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology

Process:

GO:0001781; neutrophil apoptotic process
GO:0001878; response to yeast
GO:0002384; hepatic immune response
GO:0002446; neutrophil mediated immunity
GO:0002548; monocyte chemotaxis
GO:0002675; positive regulation of acute inflammatory response
GO:0002690; positive regulation of leukocyte chemotaxis
GO:0006469; negative regulation of protein kinase activity
GO:0006953; acute-phase response
GO:0006954; inflammatory response
GO:0006959; humoral immune response
GO:0007568; aging
GO:0008284; positive regulation of cell proliferation
GO:0008285; negative regulation of cell proliferation
GO:0008360; regulation of cell shape
GO:0009408; response to heat
GO:0009409; response to cold
GO:0010574; regulation of vascular endothelial growth factor production
GO:0010628; positive regulation of gene expression
GO:0010888; negative regulation of lipid storage
GO:0010976; positive regulation of neuron projection development
GO:0010996; response to auditory stimulus
GO:0016049; cell growth
GO:0019221; cytokine-mediated signaling pathway
GO:0030168; platelet activation
GO:0031000; response to caffeine
GO:0031018; endocrine pancreas development
GO:0031175; neuron projection development
GO:0031294; lymphocyte costimulation
GO:0031669; cellular response to nutrient levels
GO:0032494; response to peptidoglycan
GO:0032722; positive regulation of chemokine production
GO:0032755; positive regulation of interleukin-6 production
GO:0032868; response to insulin
GO:0032966; negative regulation of collagen biosynthetic process
GO:0033138; positive regulation of peptidyl-serine phosphorylation
GO:0033160; positive regulation of protein import into nucleus, translocation
GO:0035729; cellular response to hepatocyte growth factor stimulus
GO:0042102; positive regulation of T cell proliferation
GO:0042493; response to drug
GO:0042517; positive regulation of tyrosine phosphorylation of Stat3 protein
GO:0042593; glucose homeostasis
GO:0042832; defense response to protozoan
GO:0043065; positive regulation of apoptotic process
GO:0043066; negative regulation of apoptotic process
GO:0043154; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043200; response to amino acid
GO:0043410; positive regulation of MAPK cascade
GO:0045079; negative regulation of chemokine biosynthetic process
GO:0045188; regulation of circadian sleep/wake cycle, non-REM sleep
GO:0045429; positive regulation of nitric oxide biosynthetic process
GO:0045454; cell redox homeostasis
GO:0045599; negative regulation of fat cell differentiation
GO:0045630; positive regulation of T-helper 2 cell differentiation
GO:0045669; positive regulation of osteoblast differentiation
GO:0045721; negative regulation of gluconeogenesis
GO:0045727; positive regulation of translation
GO:0045740; positive regulation of DNA replication
GO:0045765; regulation of angiogenesis
GO:0045779; negative regulation of bone resorption
GO:0045837; negative regulation of membrane potential
GO:0045893; positive regulation of transcription, DNA-templated
GO:0045944; positive regulation of transcription from RNA polymerase II promoter
GO:0046427; positive regulation of JAK-STAT cascade
GO:0046677; response to antibiotic
GO:0046716; muscle cell cellular homeostasis
GO:0046849; bone remodeling
GO:0046888; negative regulation of hormone secretion
GO:0048635; negative regulation of muscle organ development
GO:0048661; positive regulation of smooth muscle cell proliferation
GO:0050679; positive regulation of epithelial cell proliferation
GO:0050710; negative regulation of cytokine secretion
GO:0050731; positive regulation of peptidyl-tyrosine phosphorylation
GO:0050829; defense response to Gram-negative bacterium
GO:0050830; defense response to Gram-positive bacterium
GO:0050871; positive regulation of B cell activation
GO:0051024; positive regulation of immunoglobulin secretion
GO:0051091; positive regulation of sequence-specific DNA binding transcription factor activity
GO:0051092; positive regulation of NF-kappaB transcription factor activity
GO:0051384; response to glucocorticoid
GO:0051592; response to calcium ion
GO:0051602; response to electrical stimulus
GO:0051607; defense response to virus
GO:0051897; positive regulation of protein kinase B signaling
GO:0051971; positive regulation of transmission of nerve impulse
GO:0060445; branching involved in salivary gland morphogenesis
GO:0060664; epithelial cell proliferation involved in salivary gland morphogenesis
GO:0070091; glucagon secretion
GO:0070102; interleukin-6-mediated signaling pathway
GO:0070301; cellular response to hydrogen peroxide
GO:0070374; positive regulation of ERK1 and ERK2 cascade
GO:0071222; cellular response to lipopolysaccharide
GO:0071347; cellular response to interleukin-1
GO:0071356; cellular response to tumor necrosis factor
GO:0071392; cellular response to estradiol stimulus
GO:0071549; cellular response to dexamethasone stimulus
GO:0071864; positive regulation of cell proliferation in bone marrow
GO:0072540; T-helper 17 cell lineage commitment
GO:1901215; negative regulation of neuron death
GO:1990646; cellular response to prolactin
GO:2000366; positive regulation of STAT protein import into nucleus
GO:2000553; positive regulation of T-helper 2 cell cytokine production
GO:2000660; negative regulation of interleukin-1-mediated signaling pathway
GO:2000676; positive regulation of type B pancreatic cell apoptotic process

Cellular component:

GO:0005576; extracellular region
GO:0005615; extracellular space
GO:0005737; cytoplasm
GO:0005896; interleukin-6 receptor complex
GO:0009897; external side of plasma membrane

Function:

GO:0005125; cytokine activity
GO:0005138; interleukin-6 receptor binding
GO:0005515; protein binding
GO:0008083; growth factor activity

Hide GO terms

Protein interactions and network

No interactions in records.

Retrieve sequences for IL6

Promoter: Promoter
ORF: ORF
CDS: CDS

Homologs in model organisms

Mus musculus: Il6
Rattus norvegicus: Il6

In other databases

LongevityMap

This gene is present as IL6

CellAge

This gene is present as IL6