GenAge entry for NCOR1 (Homo sapiens)
Gene name (HAGRID: 43)
- HGNC symbol
- NCOR1
- Aliases
- N-CoR; hCIT529I10; TRAC1; hN-CoR; KIAA1047; MGC104216; PPP1R109
- Common name
- nuclear receptor corepressor 1
Potential relevance to the human ageing process
- Main reason for selection
- Entry selected based on evidence showing that the gene product to be a target of genes previously linked to ageing
- Description
NCOR1 is a transcriptional mediator that regulates chromatin condensation. Its exact functions are unknown but there is evidence linking NCOR1 to development [353]. Although there is little evidence to suggest NCOR1 influences ageing, due to its relation with several proteins thought to be related to ageing and age-related diseases [691]. Additionally, NCOR1 knockout mice, although more obese than wild type, display a significant increase in glucose tolerance, enhanced insulin sensitivity and decreased adipose tissue inflammation [3658]. NCOR1 might potentially play some role in human ageing.
Cytogenetic information
- Cytogenetic band
- 17p11.2
- Location
- 16,030,094 bp to 16,215,560 bp
- Orientation
- Minus strand
Protein information
- Gene Ontology
-
Process: GO:0000122; negative regulation of transcription from RNA polymerase II promoter
GO:0006366; transcription from RNA polymerase II promoter
GO:0007623; circadian rhythm
GO:0016569; covalent chromatin modification
GO:0044255; cellular lipid metabolic process
GO:0046329; negative regulation of JNK cascade
GO:0051225; spindle assembly
GO:0072362; regulation of glycolytic process by negative regulation of transcription from RNA polymerase II promoter
GO:0072368; regulation of lipid transport by negative regulation of transcription from RNA polymerase II promoter
GO:1903799; negative regulation of production of miRNAs involved in gene silencing by miRNA
GO:2000191; regulation of fatty acid transport
Cellular component: GO:0000118; histone deacetylase complex
GO:0000790; nuclear chromatin
GO:0005634; nucleus
GO:0005654; nucleoplasm
GO:0005876; spindle microtubule
GO:0016020; membrane
GO:0016580; Sin3 complex
GO:0017053; transcriptional repressor complex
Hide GO termsFunction: GO:0001102; RNA polymerase II activating transcription factor binding
GO:0003714; transcription corepressor activity
GO:0005515; protein binding
GO:0016922; ligand-dependent nuclear receptor binding
GO:0035257; nuclear hormone receptor binding
GO:0042826; histone deacetylase binding
GO:0044212; transcription regulatory region DNA binding
GO:0046966; thyroid hormone receptor binding
Protein interactions and network
- Protein-protein interacting partners in GenAge
- POU1F1, TP53, HDAC3, MYC, PPARA, CREBBP, NR3C1, NFKB1, UBE2I, CEBPB, EP300, PML, HTT, AR, EMD, SIRT1, YWHAZ, SP1, JUN, HESX1, CREB1, SIN3A, ESR1, NFKBIA, PPP1CA, PPARG, NCOR2, NFE2L2, CDKN1A, SQSTM1
- STRING interaction network
