GenAge entry for POU1F1 (Homo sapiens)

Entry selected based on evidence directly linking the gene product to ageing in a mammalian model organism

Gene name (HAGRID: 4)

HGNC symbol: POU1F1
Aliases: GHF-1; POU1F1a; PIT1
Common name: POU class 1 homeobox 1

Potential relevance to the human ageing process

Main reason for selection

Entry selected based on evidence directly linking the gene product to ageing in a mammalian model organism

Description

The POU1F1 transcription factor is expressed in the pituitary where it regulates pituitary development and hormone expression. It activates growth hormone (GH1) and is involved in mammalian development.

Snell dwarf mouse are a strain mutant for POU1F1 that live significantly longer than controls and show signs of ageing retardation [5]. POU1F1 abnormalities have been reported in humans associated with lower levels of GH1, prolactin, and thyroid-stimulating hormone, but with little or no evidence of an impact on ageing [233].

Cytogenetic information

Cytogenetic band: 3p11
Location: 87,259,633 bp to 87,276,587 bp
Orientation: Minus strand

Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology

Process:

GO:0000122; negative regulation of transcription from RNA polymerase II promoter
GO:0001708; cell fate specification
GO:0006355; regulation of transcription, DNA-templated
GO:0006366; transcription from RNA polymerase II promoter
GO:0008284; positive regulation of cell proliferation
GO:0008285; negative regulation of cell proliferation
GO:0008340; determination of adult lifespan
GO:0030183; B cell differentiation
GO:0032962; positive regulation of inositol trisphosphate biosynthetic process
GO:0040018; positive regulation of multicellular organism growth
GO:0043567; regulation of insulin-like growth factor receptor signaling pathway

And 5 more GO terms

Cellular component:

GO:0005634; nucleus
GO:0005654; nucleoplasm
GO:0005667; transcription factor complex
GO:0005737; cytoplasm

Function:

GO:0000978; RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000981; RNA polymerase II transcription factor activity, sequence-specific DNA binding
GO:0001077; transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0001085; RNA polymerase II transcription factor binding
GO:0001102; RNA polymerase II activating transcription factor binding
GO:0001105; RNA polymerase II transcription coactivator activity
GO:0003682; chromatin binding
GO:0003700; transcription factor activity, sequence-specific DNA binding
GO:0003714; transcription corepressor activity

Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge: NCOR1, PPARA, CREBBP, NR3C1, JUN, MED1, PPARG
STRING interaction network

Retrieve sequences for POU1F1

ORF: ORF
CDS: CDS

Homologs in model organisms

Danio rerio: pou1f1
Mus musculus: Pou1f1
Rattus norvegicus: Pou1f1

In other databases

GenAge model organism genes

A homolog of this gene for Mus musculus is present as Pou1f1