GenAge entry for NFKB2 (Homo sapiens)

Gene name (HAGRID: 20)

HGNC symbol: NFKB2
Aliases: LYT-10; p52; p105; NF-kB2
Common name: nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)

Potential relevance to the human ageing process

Main reason for selection: Entry selected based on evidence linking the gene product to a pathway or mechanism linked to ageing
Description: NFKB2 is a component of the NF-kappa-B complex, involved in oxidative pathways and a myriad of other processes. Its role in ageing is unclear, even though NFKB2 appears to be related to age-related changes in inflammation and maybe in other age-related processes too [260]. In addition, age-relation changes in NF-kappa-B have been reported for numerous tissues [261].

Cytogenetic information

Cytogenetic band: 10q24
Location: 102,395,596 bp to 102,402,529 bp
Orientation: Plus strand

Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology

Process:

GO:0000122; negative regulation of transcription from RNA polymerase II promoter
GO:0002268; follicular dendritic cell differentiation
GO:0002467; germinal center formation
GO:0006355; regulation of transcription, DNA-templated
GO:0006366; transcription from RNA polymerase II promoter
GO:0006954; inflammatory response
GO:0007249; I-kappaB kinase/NF-kappaB signaling
GO:0007568; aging
GO:0030198; extracellular matrix organization
GO:0032481; positive regulation of type I interferon production
GO:0032496; response to lipopolysaccharide
GO:0034097; response to cytokine
GO:0038061; NIK/NF-kappaB signaling
GO:0045087; innate immune response
GO:0045944; positive regulation of transcription from RNA polymerase II promoter
GO:0048511; rhythmic process
GO:0048536; spleen development
GO:0051092; positive regulation of NF-kappaB transcription factor activity

Cellular component:

GO:0005634; nucleus
GO:0005654; nucleoplasm
GO:0005737; cytoplasm
GO:0005829; cytosol
GO:0033257; Bcl3/NF-kappaB2 complex

Function:

GO:0000978; RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077; transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0003682; chromatin binding
GO:0003700; transcription factor activity, sequence-specific DNA binding
GO:0003713; transcription coactivator activity
GO:0005515; protein binding

Hide GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge: NFKB2, STAT3, VCP, NR3C1, NFKB1, RELA, SP1, NFKBIA, EPS8
STRING interaction network

Retrieve sequences for NFKB2

ORF: ORF
CDS: CDS

Homologs in model organisms

Danio rerio: nfkb2
Mus musculus: Nfkb2
Rattus norvegicus: Nfkb2

In other databases

CellAge

This gene is present as NFKB2