GenAge entry for EPS8 (Homo sapiens)

Entry selected based on evidence directly linking the gene product to ageing in a mammalian model organism

Gene name (HAGRID: 267)

HGNC symbol: EPS8
Aliases
Common name: epidermal growth factor receptor pathway substrate 8

Potential relevance to the human ageing process

Main reason for selection: Entry selected based on evidence directly linking the gene product to ageing in a mammalian model organism
Description: EPS8 knockout mice appear to be caloric restricted, most probably due to an impaired fat absorption, and show a lean phenotype and increased lifespan [2158]. EPS8 was also shown to be involved in several type of cancer [2161].

Cytogenetic information

Cytogenetic band: 12p12.3
Location: 15,620,141 bp to 15,789,576 bp
Orientation: Minus strand

Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology

Process:

GO:0007165; signal transduction
GO:0007173; epidermal growth factor receptor signaling pathway
GO:0008283; cell proliferation
GO:0008344; adult locomotory behavior
GO:0008360; regulation of cell shape
GO:0009967; positive regulation of signal transduction
GO:0010458; exit from mitosis
GO:0016601; Rac protein signal transduction
GO:0030832; regulation of actin filament length
GO:0031532; actin cytoskeleton reorganization
GO:0036336; dendritic cell migration

And 6 more GO terms

Cellular component:

GO:0005903; brush border
GO:0005938; cell cortex
GO:0014069; postsynaptic density
GO:0017146; NMDA selective glutamate receptor complex
GO:0030054; cell junction
GO:0030426; growth cone
GO:0031982; vesicle
GO:0032420; stereocilium
GO:0032587; ruffle membrane
GO:0070062; extracellular exosome

Function:

GO:0003779; actin binding
GO:0005070; SH3/SH2 adaptor activity
GO:0005515; protein binding
GO:0048365; Rac GTPase binding

Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge: SHC1, NFKB2, EGFR, XRCC6, GRB2, EPS8
STRING interaction network

Retrieve sequences for EPS8

ORF: ORF
CDS: CDS

Homologs in model organisms

Danio rerio: eps8
Mus musculus: Eps8
Rattus norvegicus: Eps8

In other databases

GenAge model organism genes

A homolog of this gene for Mus musculus is present as Eps8