GenAge entry for NGF (Homo sapiens)

Gene name (HAGRID: 31)

HGNC symbol: NGF
Aliases: NGFB
Common name: nerve growth factor (beta polypeptide)

Potential relevance to the human ageing process

Main reason for selection: Entry selected based on indirect or inconclusive evidence linking the gene product to ageing in humans or in one or more model systems
Description: A neurotrophin important for the development and maintenance of the central nervous system, NGF stimulates division and differentiation [319]. It has been linked with neurodegenerative age-related pathology [318].

Cytogenetic information

Cytogenetic band: 1p13.1
Location: 115,285,916 bp to 115,338,236 bp
Orientation: Minus strand

Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology

Process:

GO:0000186; activation of MAPKK activity
GO:0006919; activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0007018; microtubule-based movement
GO:0007169; transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007267; cell-cell signaling
GO:0008625; extrinsic apoptotic signaling pathway via death domain receptors
GO:0010628; positive regulation of gene expression
GO:0032455; nerve growth factor processing
GO:0043065; positive regulation of apoptotic process
GO:0043066; negative regulation of apoptotic process
GO:0043154; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043281; regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043524; negative regulation of neuron apoptotic process
GO:0045664; regulation of neuron differentiation
GO:0046579; positive regulation of Ras protein signal transduction
GO:0048011; neurotrophin TRK receptor signaling pathway
GO:0048015; phosphatidylinositol-mediated signaling
GO:0048812; neuron projection morphogenesis
GO:0050772; positive regulation of axonogenesis

Cellular component:

GO:0005576; extracellular region
GO:0005768; endosome
GO:0005796; Golgi lumen

Function:

GO:0005163; nerve growth factor receptor binding
GO:0005515; protein binding
GO:0008083; growth factor activity
GO:0008191; metalloendopeptidase inhibitor activity

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Protein interactions and network

Protein-protein interacting partners in GenAge: NGFR, A2M
STRING interaction network

Retrieve sequences for NGF

ORF: ORF
CDS: CDS

Homologs in model organisms

Danio rerio: ntf7
Mus musculus: Ngf
Rattus norvegicus: Ngf